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Untersuchungen uber die Harnstoffbildung im Tierkörper
Abstract
Das Hauptergebnis dieser Arbeit ist die Auffindung des Weges, auf dem im tierischen Organismus die Synthese des Harnstoffs aus Ammoniak und Kohlensaure verlauft. Die Harnstoffsynthese ist an das Vorhandensein von Ornithin gebunden, ohne das Ornithin in der Bilanz der Synthese verbraucht wird. Ornithin, Ammoniak und Kohlensaure treten unter Wasseraustritt zu einer Guanidinoverbindung — dem Arginin — zusammen [Reaktion (1)]. Arginin spaltet durch die Wirkungder Arginase Harnstoffab [Reaktion (2)] und liefert Ornithin zuruck, das wieder fur Reaktion (1) zur Verfugung steht.
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Cited by
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Kanyo, Z. F., Scolnick, L. R., Ash, D. E., & Christianson, D. W. (1996) · Nature · doi:10.1038/383554a0 · Cited by 441
Zierath, J. R., He, L., Gumà, A., Wahlström, E. O., Klip, A., & Wallberg-Henriksson, H. (1996) · Diabetologia · doi:10.1007/bf02658504 · Cited by 402
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SOLARO, R. J., MOIR, A. J. G., & PERRY, S. V. (1976) · Nature · doi:10.1038/262615a0 · Cited by 395
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Cartee, G. D., Young, D. A., Sleeper, M. D., Zierath, J., Wallberg-Henriksson, H., & Holloszy, J. O. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.4.e494 · Cited by 342
Metadata
- Authors
- Krebs, H. A., & Henseleit, K.
- Venue
- Hoppe-Seyler´s Zeitschrift für physiologische Chemie
- Publisher
- Walter de Gruyter GmbH
- Published
- 1932-01
- Volume
- 210
- Issue
- 1-2
- Pages
- 33-66
- ISSN
- 0018-4888 (ISSN-L)
- OpenAlex
- W2432195370
- Cited by
- 3,100
- References
- 0
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krebs, H. A., & Henseleit, K. (1932). Untersuchungen uber die Harnstoffbildung im Tierkörper. Hoppe-Seyler´s Zeitschrift für physiologische Chemie. https://doi.org/10.1515/bchm2.1932.210.1-2.33
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