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Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study
Abstract
BACKGROUND: The use of biomarkers is firmly established for the assessment of cardiovascular disease. Emerging biomarkers such as midregional pro-atrial natriuretic peptide (MR-proANP) challenge established markers regarding risk prediction and stratification ability. The aim of the present study was to describe the distribution of a contemporary MR-proANP assay in a large population-representative sample and to evaluate the association with prevalent cardiac diseases and cardiovascular risk factors. METHODS: MR-proANP was determined by the use of a contemporary commercially available assay (BRAHMS GmbH, Hennigsdorf, Germany) in a representative sample of 5000 participants from the large population-based Gutenberg Health Study. N-terminal pro B-type natriuretic peptide (NT-proBNP) was used as a comparator. RESULTS: Mean age was 55.5 ± 10.9 years. Coronary artery disease (CAD) was documented in 4.6%, heart failure (HF) in 1.5% of the study participants. We observed a moderate to strong correlation of the biomarkers with age, diabetes, hypertension, smoking, renal function, prevalence of CAD and HF. Males showed lower MR-proANP concentrations than females. MR-proANP showed no relevant correlation with BMI (ρ=-0.030) and CRP (ρ=0.039). Reference limits for MR-proANP representing the 95th/97.5th/99th percentile were determined for healthy individuals with 116/132/169 pmol/mL. CONCLUSIONS: The current analysis in a large population-based sample elucidates the correlations and distribution of MR-proANP. Its concentration in healthy individuals depends on prevalent cardiovascular diseases and classical risk factors. The reported population-based reference values might be useful for distinguishing between healthy and diseased individuals, thus improving risk stratification and triaging in various clinical settings.
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Increased natriuretic peptide levels are associated with CVD and early heart failure, whereas overweight and insulin resistance decrease ANP levels.
“Increased levels of the NPs are associated with CVD and early heart failure (9), but in contrast large cohort studies have shown that overweight and insulin resistance decrease levels of ANP (10).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [9]
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References 21 · Cited by 22
Research works printed but not linked: 39
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- ACCF, 2007, Joint AHA WHF Task Force for the Redefinition of Myocardial Infarction HD Group AS Universal definition of myocardial infarction Thygesen on behalf of the Joint AHA WHF Task Force for the Redefinition of Myocardial Infarction, Eur Heart J, 28, 2525, 10.1093/eurheartj/ehm355 · DOI
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Metadata
- Authors
- Tzikas, S., Keller, T., Wild, P. S., Schulz, A., Zwiener, I., Zeller, T., Schnabel, R. B., Sinning, C., Lubos, E., Kunde, J., Münzel, T., Lackner, K. J., & Blankenberg, S.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universität Hamburg (DE)
- Thermo Fisher Scientific (Germany) (DE)
- Corresponding author
- Tzikas, Stergios
- ORCID
- Venue
- Clinical Chemistry and Laboratory Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2013-01-01
- Volume
- 51
- Issue
- 5
- Pages
- 1125-33
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2008129356
- Cited by
- 22
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- MR-proANP, natriuretic peptides, cardiovascular biomarkers, reference values, coronary artery disease, heart failure, cardiovascular risk factors, sex differences, NT-proBNP, risk stratification, Gutenberg Health Study
- MeSH terms
- Adult, Aged, Blood Chemical Analysis, Cross-Sectional Studies, Female, Germany, Humans, Male, Middle Aged, Atrial Natriuretic Factor, Cohort Studies, Biomarkers
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