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Cited by 110Metabolomics and Mass Spectrometry StudiesNutritional Studies and DietMetabolism and Genetic Disorders

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Intra-individual variation of plasma trimethylamine-N-oxide (TMAO), betaine and choline over 1 year

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Kühn, Tilman, Rohrmann, Sabine, Sookthai, Disorn, Johnson, Theron, Katzke, Verena, Kaaks, Rudolf, von Eckardstein, Arnold, Müller, Daniel·2017·Clinical Chemistry and Laboratory Medicine (CCLM)
DOI 10.1515/cclm-2016-0374
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Abstract

BACKGROUND: Circulating trimethylamine-N-oxide (TMAO) has been implicated in the development of cardiovascular and chronic kidney diseases (CKD). However, while higher TMAO levels have been associated with increased risks of cardiovascular or renal events in first prospective studies, it remained unclear how much plasma TMAO concentrations vary over time. METHODS: We measured fasting plasma levels of TMAO and two of its precursors, betaine and choline by LC-MS, in two samples of 100 participants of the European Investigation into Cancer and Nutrition (EPIC)-Heidelberg study (age range: 47-80 years, 50% female) that were collected 1 year apart, and assessed their intra-individual variation by Spearman's correlation coefficients (ρ). RESULTS: Correlations of metabolite concentrations over 1 year were at ρ=0.29 (p=0.003) for TMAO, ρ=0.81 (p<0.001) for betaine, and ρ=0.61 (p<0.001) for choline. Plasma levels of TMAO were not significantly associated with food intake, lifestyle factors, or routine biochemistry parameters such as C-reactive protein (CRP), low-density lipoprotein (LDL)-cholesterol, or creatinine. CONCLUSIONS: In contrast to fasting plasma concentrations of betaine and choline, concentrations of TMAO were more strongly affected by intra-individual variation over 1 year in adults from the general population. The modest correlation of TMAO levels over time should be considered when interpreting associations between TMAO levels and disease endpoints.

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Metadata

Authors
Kühn, T., Rohrmann, S., Sookthai, D., Johnson, T., Katzke, V., Kaaks, R., von Eckardstein, A., & Müller, D.
Affiliations
  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany , Phone: +49 6221 42 3184, Fax: +49 6221 42 2203
  • University of Zurich (CH)
  • German Cancer Research Center (DE)
  • Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
  • University Hospital Zurich (CH)
ORCID
Venue
Clinical Chemistry and Laboratory Medicine (CCLM)
Publisher
Walter de Gruyter GmbH
Published
2016-07-22
Volume
55
Issue
2
Pages
261-268
ISSN
  • 1434-6621 (ISSN-L)
  • 1437-4331
DOI
10.1515/cclm-2016-0374
OpenAlex
W2481133299
Cited by
110
References
38
Citations by year
2026: 4 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 12 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 5
FWCI
6.06
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Deutsches Krebsforschungszentrum
  • Bundesministerium für Bildung und Forschung (01ER0809)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
trimethylamine N-oxide, betaine, choline, within-person variability, cardiovascular disease, chronic kidney disease, dietary precursors, EPIC-Heidelberg cohort
MeSH terms
Aged, Aged, 80 and over, Betaine, Choline, Chromatography, Liquid, Female, Humans, Male, Methylamines, Middle Aged, Mass Spectrometry, Time Factors

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