Standardization and harmonization of autoimmune diagnostics
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The expression of anti-dsDNA comprises a mixture of antibodies and fine specificities.
“This is particularly apt for antibodyspecificity testing in the context of autoimmune disease since the expression of anti-dsDNA comprises a mixture of antibodies and fine specificities (6,72).”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [72]
The Conclusions describe autoantibodies as complex analytes that vary between patients, and ‘Detection of autoantibodies: what do we measure?’ identifies anti-dsDNA as an autoantibody. That section also discusses differences in antibody selectivity, affinity and avidity, but does not specifically say that anti-dsDNA comprises a mixture of antibodies with distinct fine specificities. The indexed passages provide no page numbers. (LLM, conf=0.78)
Experimental — accuracy not yet measuredDifferences in the tests could hamper efforts toward test harmonization in autoimmune diagnostics.
“While the differences in the tests could hamper efforts toward test harmonization in autoimmune diagnostics (72), this is also an opportunity to adopt complimentary diagnostic approaches depending on the setting, such as a combination of a sensitive and a highly specific test (6).”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [72]
Anti-dsDNA tests of differing design may lead to the differential classification of patients, as is the case for other autoantibodies such as rheumatoid factor and anti-CCP antibodies.
“Anti-dsDNA tests of differing design may lead to the differential classification of patients, as is the case for other autoantibodies (e.g., rheumatoid factor and anti-CCP antibodies) (72)(73)(74).”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [72]
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References 36 · Cited by 31
- Authors
- Jacobs, J. F. M., & Bossuyt, X.
- Affiliations
- Radboud University Nijmegen (NL)
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Jacobs, Joannes F.M.
- Venue
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018-08-18
- Volume
- 56
- Issue
- 10
- Pages
- 1563-1567
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2888305006
- Cited by
- 31
- References
- 36
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 6 · 2018: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- KWF Kankerbestrijding (10817)
- Topics
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Keywords
- standardization, harmonization, laboratory test standardization
- MeSH terms
- Antibodies, Antinuclear, Autoantibodies, Autoimmune Diseases, Humans, Immunoassay, Laboratories, Hospital, Rheumatoid Factor
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