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The Bioactivity of Saponins: Triterpenoid and Steroidal Glycosides
Abstract
Triterpenoid and steroidal glycosides, referred to collectively as saponins, are bioactive compounds present naturally in many plants. They have considerable potential as pharmaceutical and/or nutraceutical agents in natural or synthetic form. Saponins, from a variety of sources, have been shown to have hypocholesterolemic, anti-coagulant, anticarcinogenic, hepatoprotective, hypoglycemic, immunomodulatory, neuroprotective, anti-inflammatory and anti-oxidant activity. This paper reviews saponin research of the last decade, focussing on developments in understanding their mechanism of action and structure-activity relationships. Virtually all of this work has used animal and in vitro models. To date there are very few human data.
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Cited by
Ma, Y., Zhao, Y., Luo, M., Jiang, Q., Liu, S., Jia, Q., Bai, Z., Wu, F., & Xie, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1393409 · Cited by 44
Metadata
- Authors
- Rao, & Gurfinkel
- Venue
- Drug Metabolism and Drug Interactions
- Publisher
- Walter de Gruyter GmbH
- Published
- 2000-12
- Volume
- 17
- Issue
- 1-4
- Pages
- 211-236
- ISSN
- 0334-2190 (ISSN-L)
- 2191-0162
- 0792-5077
- OpenAlex
- W2042267700
- Cited by
- 274
- References
- 0
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rao, & Gurfinkel. (2000). The Bioactivity of Saponins: Triterpenoid and Steroidal Glycosides. Drug Metabolism and Drug Interactions. https://doi.org/10.1515/dmdi.2000.17.1-4.211
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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