Expression and translation of the COX-1b gene in human cells – no evidence of generation of COX-1b protein

Reinauer, Christina; Censarek, Petra; Kaber, Gernot; Weber, Artur-Aron; Steger, Gerhard; Klamp, Thorsten; Schrör, Karsten

doi:10.1515/hsz-2012-0309

Expression and translation of the COX-1b gene in human cells – no evidence of generation of COX-1b protein

Cyclooxygenase 1b ( COX-1b ) is a splice variant of COX-1, containing a retained intron 1 within the signal peptide sequence. COX-1b mRNA is found in many species, but the existence of a functionally active protein, which is possibly related to different species-dependent lengths of intron 1, is …