Bisphosphonates in children with osteogenesis imperfecta may improve bone mineralization but not bone strength. Report of two patients
Abstract
Article Bisphosphonates in Children with Osteogenesis Imperfecta may Improve Bone Mineralization but not Bone Strength. Report of Two Patients was published on July 1, 1999 in the journal Journal of Pediatric Endocrinology and Metabolism (volume 12, issue 4).
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The use of bisphosphonates is not ideal in a growing skeleton because they inhibit bone remodeling and could increase the mineral in the bone matrix.
“However, as bone is highly remodeled during childhood to maintain adequate mineralization of the rapidly growing skeleton, the use of BPs is not ideal as they inhibit bone remodeling and could increase the mineral in the bone matrix, which may not be ideal to use in a growing skeleton [16, 17].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [16]
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References 8 · Cited by 32
- Authors
- Roldán, E. J. A., Pasqualini, Τ., & Plantalech, L.
- ORCID
- Plantalech, L.
- Venue
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Published
- 1999-01
- Volume
- 12
- Issue
- 4
- Pages
- 555-9
- ISSN
- 0334-018X (ISSN-L)
- 2191-0251
- OpenAlex
- W2315416901
- Cited by
- 32
- References
- 8
- Citations by year
- 2026: 1 · 2025: 2 · 2021: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatological and Skeletal Disorders
- Keywords
- bisphosphonates, osteogenesis imperfecta, children, bone mineralization, bone strength, pediatric bone disease
- MeSH terms
- Pamidronate, Biomechanical Phenomena, Bone and Bones, Child, Diphosphonates, Humans, Male, Osteogenesis Imperfecta, Tensile Strength, Tomography, X-Ray Computed, Absorptiometry, Photon, Bone Density, Torque
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