Anti-epileptic Drugs and Thyroid Function
Abstract
Antiepileptic drugs (AED) are a heterogeneous group of compounds widely used in both adults and children. These drugs are related to various adverse effects involving several organs and endocrinological and metabolic functions. In particular, relevant effects on thyroid function have been described. Subclinical hypothyroidism and alterations in thyroid hormone serum levels are reported in the literature; phenytoin, valproate and carbamazepine, in particular, seem to be involved in these alterations. The aim of this review is to analyse critically the principal alterations in thyroid function caused by AED therapy.
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Subclinical hypothyroidism may occur reversibly following administration of antiepileptic drugs, particularly carbamazepine, phenytoin, valproate, oxcarbazepine, but not lamotrigine, levetiracetam, tiagabine and vigabatrin.
“SCH may occur reversibly following administration of antiepileptic drugs (AED), particularly carbamazepine, phenytoin, valproate (77), oxcarbazepine, but not lamotrigine, levitracetam, tiagabine and vigabatrine (36).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [77]
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References 26 · Cited by 45
- Authors
- Verrotti, A., Scardapane, A., Manco, R., & Chiarelli, F.
- Affiliations
- University of Chieti-Pescara (IT)
- Venue
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Published
- 2008-01
- Volume
- 21
- Issue
- 5
- Pages
- 401-8
- ISSN
- 0334-018X (ISSN-L)
- 2191-0251
- OpenAlex
- W2048567057
- Cited by
- 45
- References
- 26
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- antiepileptic drugs, thyroid function, subclinical hypothyroidism, phenytoin, valproic acid, carbamazepine, drug-induced thyroid dysfunction, adverse drug reactions, serum thyroid hormones
- MeSH terms
- Anticonvulsants, Carbamazepine, Humans, Phenytoin, Thyroid Gland, Thyroid Hormones, Valproic Acid
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