Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure
Abstract
Maternal adrenal cortical carcinoma in pregnancy is rare. We report a case of an infant born to a mother with a history of adrenal cortical carcinoma. The pregnancy was complicated by fetal exposure to mitotane and dexamethasone. Despite the potential teratogenic exposures, there was no evidence of adrenal dysfunction in the infant. Growth and development at 12 months of age are normal and prognosis appears favorable. The long-term impact of fetal exposure to mitotane and glucocorticoid requires further investigation.
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At least 6 pregnancies with conception during or shortly after mitotane therapy have been reported; four children were born evidently healthy, and no birth defects were encountered.
“At least 6 pregnancies with conception during or shortly after mitotane therapy have been reported. Four children were born evidently healthy, and no birth defects were encountered (305–307).”
From Adrenocortical carcinoma (2014) · cites this paper as [307]
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References 6 · Cited by 14
- Authors
- Kojori, F., Cronin, C. M. G., Salamon, E., Burym, C., & Sellers, E. A. C.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Sellers, Elizabeth Ann Cameron
- Venue
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011-01-01
- Volume
- 24
- Issue
- 3-4
- Pages
- 203-4
- ISSN
- 0334-018X (ISSN-L)
- 2191-0251
- OpenAlex
- W2017103119
- Cited by
- 14
- References
- 6
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- pregnancy, mitotane, dexamethasone, fetal glucocorticoid exposure, teratogenicity, adrenal function, infants, adrenal insufficiency, fetal growth and development
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenal Glands, Dexamethasone, Female, Humans, Infant, Male, Mitotane, Pregnancy, Pregnancy Complications, Neoplastic, Adrenocortical Carcinoma, Maternal Exposure, Antineoplastic Agents, Hormonal, Young Adult
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