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Cited by 16Bone Tissue Engineering MaterialsNanoparticles: synthesis and applicationsAdvanced ceramic materials synthesis

Applications of nanobioceramics to healthcare technology

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Feng, Jason, Thian, Eng San·2013·Nanotechnology Reviews
DOI 10.1515/ntrev-2012-0065
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Abstract

The development of functional, biological solutions to repair or replace damaged tissues and organs is the goal of tissue engineering. This involves an interplay of cells, scaffolds and biomolecules that would generate a favourable response when implanted into patients, thus restoring functions lost or impaired due to injuries or diseases. Advances in nanotechnology have enabled the design and fabrication of novel materials at the nanometre scale. Hailed as the next generation of advanced materials, nanomaterials possess advantages of being biochemically and nanostructurally similar to that of physiological tissues. Moreover, nanotopological cues are incorporated, ensuring appropriate cellular responses, thereby enhancing the success of tissue regeneration. Nanobioceramics play a crucial role in bone tissue engineering due to its close chemical similarity to physiological bone and excellent biocompatibility. In addition, nanoscale engineering of these materials has the ability to enhance mechanical and biological properties. This review will begin with an introduction to nanomaterials and its associated considerations that should be taken into account. Next, the role of nanobioceramics achieving these considerations will be discussed. An overview of the current form of nanobioceramics being developed will be provided, concluding with an outlook of nanobioceramics for the healthcare industry.

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  • The RGD sequence exhibits specific affinity for integrin receptors expressed on cell membranes, enabling more selective recruitment of gingival fibroblasts and directing their adhesion behavior and functional activity.

    “The RGD sequence exhibits specific affinity for integrin receptors expressed on cell membranes, thereby enabling more selective recruitment of gingival fibroblasts and directing their adhesion behavior and functional activity.49”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [49]

    The Introduction (page not provided) says RGD-containing motifs are preferentially recognized by integrins on cells, and the cellular-response discussion links integrin engagement to signaling and cell behavior. The paper does not establish selective recruitment of gingival fibroblasts or RGD-directed adhesion and functional activity specifically in those cells. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.

    “In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [49]

    Section 4.3 (page unavailable) discusses hydroxyapatite and reports cell adhesion and osteogenic differentiation for substituted nano-hydroxyapatite, not PDA. Searches for polydopamine, PDA, dopamine, and dentin sealing found no passage in our copy connecting PDA to the claimed outcomes or tests. (LLM, conf=0.78)

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Authors
Feng, J., & Thian, E. S.
Affiliations
National University of Singapore (SG)
Corresponding author
Thian, Eng San
ORCID
Thian, Eng San
Venue
Nanotechnology Reviews
Publisher
Walter de Gruyter GmbH
Published
2013-12-01
Volume
2
Issue
6
Pages
679-697
ISSN
  • 2191-9089 (ISSN-L)
  • 2191-9097
DOI
10.1515/ntrev-2012-0065
OpenAlex
W2319911163
Cited by
16
References
119
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2015: 1
FWCI
0.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Nanotechnology Reviews (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Materials Science › Ceramics and Composites › Advanced ceramic materials synthesis
Keywords
tissue engineering, bone tissue engineering, nanomaterials, scaffolds, tissue regeneration, biocompatibility, mechanical properties, medical applications

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