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Cited by 19Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammationinterferon and immune responses

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Astroglial control of neuroinflammation: TLR3-mediated dsRNA-sensing pathways are in the focus

Salmina, Alla B., Komleva, Yulia K., Lopatina, Olga L., Kuvacheva, Natalia V., Gorina, Yana V., Panina, Yulia A., Uspenskaya, Yulia A., Petrova, Marina M., Demko, Irina V., Zamay, Anna S., Malinovskaya, Natalia A.·2015·Reviews in the Neurosciences
DOI 10.1515/revneuro-2014-0052
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Abstract

Neuroinflammation is as an important component of pathogenesis in many types of brain pathology. Immune mechanisms regulate neuroplasticity, memory formation, neurogenesis, behavior, brain development, cognitive functions, and brain metabolism. It is generally believed that essential homeostatic functions of astrocytes - astroglia-neuron metabolic coupling, gliovascular control, regulation of proliferation, and migration of cells in the neurogenic niches - are compromised in neuroinflammation resulting in excitotoxicity, neuronal and glial cell death, and alterations of intercellular communication. Viral neuroinfection, release of non-coding RNAs from the cells at the sites of brain injury or degeneration, and application of siRNA or RNA aptamers as therapeutic agents would require dsRNA-sensing pathways in the cells of neuronal and non-neuronal origin. In this review, we analyze the data regarding the role of astrocytes in dsRNA-initiated innate immune response in neuroinflammation and their contribution to progression of neurodegenerative and neurodevelopmental pathology.

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Metadata

Authors
Salmina, A. B., Komleva, Y. K., Lopatina, O. L., Kuvacheva, N. V., Gorina, Y. V., Panina, Y. A., Uspenskaya, Y. A., Petrova, M. M., Demko, I. V., Zamay, A. S., & Malinovskaya, N. A.
Affiliations
Krasnoyarsk State Medical University (RU)
Corresponding author
Salmina, Alla B.
ORCID
Venue
Reviews in the Neurosciences
Publisher
Walter de Gruyter GmbH
Published
2015-01-01
Volume
26
Issue
2
Pages
143-59
ISSN
  • 0334-1763 (ISSN-L)
  • 2191-0200
DOI
10.1515/revneuro-2014-0052
OpenAlex
W2318261946
Cited by
19
References
3
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 1
FWCI
0.13
Type
journal article
Language
en
Open access
closed
Locations
  • Reviews in the Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
astrocytes, neuroinflammation, TLR3, double-stranded RNA sensing, innate immunity, viral neuroinfection, non-coding RNA, siRNA, RNA aptamers, neurodegenerative diseases, neurodevelopmental disorders
MeSH terms
Animals, Astrocytes, DNA, Humans, Signal Transduction, Neurodegenerative Diseases, Toll-Like Receptor 3, Neurogenesis

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