GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which regulates body metabolism by phosphorylation of glycogen synthase (GS) and other substrates. Considerable evidence suggests that GSK3 is involved in the common pathology underlying Alzheimer’s disease (AD) and …