The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Recent developments in CCR2 antagonists
Abstract
Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and memory T cells by means of their binding to its specific cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to the G-protein-coupled seven-transmembrane receptor superfamily. The evidence in favor of CCR2 and MCP-1 having dominant roles in monocyte chemotaxis and chronic inflammation was provided by CCR2 and MCP-1 knockout mice. It has been recognized that CCR2 antagonists are potential therapeutic agents in preventing, treating, or ameliorating a CCR2-mediated inflammatory syndrome or disease such as psoriasis, uveitis, rheumatoid arthritis, multiple sclerosis, asthma, obesity, and chronic obstructive pulmonary disease. This review summarizes recent developments in small-molecule CCR2 antagonists disclosed by patent applications published between 2005 and 2008 and related publications.
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Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497
Tsutsumi, C., Sonoda, K.-H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0902436 · Cited by 277
Cited by
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
The mast cell and allergic diseases: role in pathogenesis and implications for therapy
Brown, J. M., Wilson, T. M., & Metcalfe, D. D. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02886.x · Cited by 212
Young, L. R., Gulleman, P. M., Short, C. W., Tanjore, H., Sherrill, T., Qi, A., McBride, A. P., Zaynagetdinov, R., Benjamin, J. T., Lawson, W. E., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88947 · Cited by 105
Arfaei, R., Mikaeili, N., Daj, F., Boroumand, A., Kheyri, A., Yaraghi, P., Shirzad, Z., Keshavarz, M., Hassanshahi, G., Jafarzadeh, A., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112328 · Cited by 27
Metadata
- Authors
- Xia, M., & Sui, Z.
- Venue
- Expert Opinion on Therapeutic Patents
- Publisher
- Informa Healthcare
- Published
- 2009-03
- Volume
- 19
- Issue
- 3
- Pages
- 295-303
- ISSN
- 1354-3776 (ISSN-L)
- 1744-7674
- OpenAlex
- W2099873826
- Cited by
- 189
- References
- 3
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
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