Epidermal stem cells: an update on their potential in regenerative medicine
Abstract
Introduction Adult epidermal stem cells are crucial for skin tissue regeneration during homeostasis and disease. Recent updates relating to the function, cellular role and properties of these cells have been published. Notably, a recent study showed that keratinocytes may possess a transcriptional profile that is more amenable to reprogramming and this may open new avenues for exploring novel strategies to create patient-specific cell therapies. Areas covered In this paper, an overview of recent research pertaining to epidermal stem cells' properties and location, and their capacity for differentiation and transdifferentiation, as well as potential for tumorigenesis are presented. Expert opinion More efforts should be made to develop effective approaches to induce lineage conversion between different cell types and tailor the treatment to specific patient, while minimizing cancer risk.
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Several studies have suggested an unanticipated level of cellular plasticity within epidermal keratinocytes, resulting in cell-fate flexibility during wound repair.
“Several studies have suggested an unanticipated level of cellular plasticity within epidermal keratinocytes, resulting in cell‐fate flexibility during wound repair.[ 8 , 9 , 10 , 11 , 12 ]”
From Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin (2021) · cites this paper as [8]
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References 97 · Cited by 10
- Authors
- Sun, X., Fu, X., Han, W., Zhao, M., & Chalmers, L.
- Affiliations
- Chinese PLA General Hospital (CN)
- University of California Davis Medical Center (US)
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa Healthcare
- Published
- 2013-03-21
- Volume
- 13
- Issue
- 6
- Pages
- 901-910
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W2007633309
- Cited by
- 10
- References
- 97
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Biological Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- epidermal stem cells, keratinocytes, skin regeneration, cellular reprogramming, gene expression profiling, transdifferentiation, carcinogenesis, cell therapy, regenerative medicine
- MeSH terms
- Animals, Cell Differentiation, Epidermis, Humans, Regeneration, Skin Neoplasms, Neoplastic Stem Cells, Cell Lineage, Stem Cell Transplantation, Regenerative Medicine, Cell Proliferation, Adult Stem Cells, Cell Transdifferentiation
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