Retinoid-related orphan receptor γt is a potential therapeutic target for controlling inflammatory autoimmunity
Abstract
Retinoid-related orphan receptor gamma t (RORgamma t) is a member of the nuclear receptor family that is specifically expressed in T cell compartments. RORgamma t regulates the development of T cells in the thymus and the differentiation of effector T cells in the periphery. During T cell development, RORgamma t enhances CD4(+)CD8(+) double positive thymocyte survival by upregulating Bcl-x(L). In the periphery, RORgamma t regulates IL-17 production and dictates the differentiation of pro-inflammatory T helper 17 (T(H)17) cells that play a critical role in inflammatory conditions and autoimmunity. RORgamma t-deficient T cells fail to differentiate into T(H)17 cells, whereas forced expression of RORgamma t is sufficient to induce naive T cells to produce IL-17. T(H)17 cells are believed to be the major inflammatory cells in autoimmune diseases. Therefore, inhibition of RORgamma t activity could potentially alleviate the symptoms associated with the T(H)17-dependent inflammatory autoimmune diseases. RORgamma t is thus potentially an excellent therapeutic target for the intervention of inflammatory autoimmunity.
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RORγT is a widely used marker of Th17 cells.
“is a widely used marker of Th17 cells (49)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [49]
Methods capable of reducing Th17 cell levels in vivo are limited.
“Methods capable of reducing Th17 cell levels in vivo are limited, with RORγT knockout mice being the most widely used approach (48, 49).”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [49]
RORγT knockout mice are the most widely used approach for reducing Th17 cell levels in vivo.
“Methods capable of reducing Th17 cell levels in vivo are limited, with RORγT knockout mice being the most widely used approach (48, 49).”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [49]
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Inflammatory T helper 17 cells promote depression-like behavior in mice
Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254 · see citing works
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Self-citation
- Authors
- Huang, Z., Xie, H., Wang, R., & Sun, Z.
- Affiliations
- University of Illinois Chicago (US)
- Beckman Research Institute (US)
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa UK Limited
- Published
- 2007-05-15
- Volume
- 11
- Issue
- 6
- Pages
- 737-743
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W1971698075
- Cited by
- 61
- References
- 5
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI053147)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Th17 cells, IL-17, T cell development, Bcl-xL, T cell differentiation, nuclear receptors, therapeutic target
- MeSH terms
- Animals, Autoimmune Diseases, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Receptors, Thyroid Hormone, Drug Delivery Systems, Receptors, Retinoic Acid, Inflammation Mediators, Interleukin-17, Nuclear Receptor Subfamily 1, Group F, Member 3
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