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Cited by 53Pharmaceutical and Antibiotic Environmental ImpactsEnvironmental Chemistry and AnalysisMicrobial bioremediation and biosurfactants

Biological Removal of the Mixed Pharmaceuticals: Diclofenac, Ibuprofen, and Sulfamethoxazole Using a Bacterial Consortium

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Aissaoui, Salima, Ouled-Haddar, Houria, Sifour, Mohamed, Beggah, Chérifa, Benhamada, Farida·2017·Iranian Journal of Biotechnology
DOI 10.15171/ijb.1530PMC PMC5811055
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Abstract

Background: The presence of pharmaceuticals at low concentrations (ng to μg) in the environment has become a hot spot for researchers in the past decades due to the unknown environmental impact and the possible damages they might have to the plantae and fauna present in the aquatic systems, as well as to the other living organisms.Objectives: The aim of the present investigation was to develop a bacterial consortium isolated from diff erent origins to evaluate the ability of such a consortium to remove a mixture of pharmaceuticals in the batch system at lab scale, as well as assessment of its resistance to the other micropollutants present in the environment.Material and Methods: Using a closed bottle test, biodegradation of the mixed pharmaceuticals including Diclofenac (DCF), Ibuprofen (IBU), and Sulfamethoxazole (SMX) (at a concentration of 3 mg.L-1 of each drug) by the bacerial consortium was investigated. The test was carried out under metabolic (pharmaceutical was used as the sole source of carbon) and co-metabolic condition (in the presence of glucose). Finally, the ability of the bacterial consortium to resist other micropollutants like antibiotics and heavy metals was investigated.Results: Under the metabolic condition, the mixed bacteria (i.e., consortium) were able to metabolize 23.08% and 9.12% of IBU, and DCF at a concentration of 3 mg.L-1 of each drug, respectively. Whereas, in co-metabolic conditions, IBU was eliminated totally, in addition, 56% of the total concentration of DCF was removed, as well. In both metabolic and cometabolic conditions, removal of SMX was not observed. The selected bacteria were able to resist to most of the applied antibiotics and the used heavy metals, except mercury, where only one strain (S4) was resistant to the later heavy metal. Conclusion: Results suggest that the developed consortium might be an excellent candidate for the application in thebioremediation process for treating ecosystems contaminated with the pharmaceutical.

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Cited by

Sorted by citations

Authors
Aissaoui, S., Ouled-Haddar, H., Sifour, M., Beggah, C., & Benhamada, F.
Affiliations
University of Jijel (DZ)
ORCID
Venue
Iranian Journal of Biotechnology
Publisher
Armenian Green Publishing Co.
Published
2017-08-19
Volume
15
Issue
2
Pages
135-142
ISSN
  • 1728-3043 (ISSN-L)
  • 2322-2921
DOI
10.15171/ijb.1530
PMC
PMC5811055
OpenAlex
W2658900390
Cited by
53
References
0
Citations by year
2026: 7 · 2025: 11 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 2
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Iranian Journal of Biotechnology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
  • Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
Keywords
pharmaceutical micropollutants, diclofenac, ibuprofen, sulfamethoxazole, bacterial consortium, biodegradation, cometabolism, antibiotic resistance, heavy metal resistance, bioremediation

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