The DOI matches its Crossref record, with a small difference in title or year; 56 of the 56 references it cites were found in a registry or an index.
Aerobic Exercise Sustains Performance of Instrumental Activities of Daily Living in Early-Stage Alzheimer Disease
Open accessAbstract
BACKGROUND AND PURPOSE: Individuals with Alzheimer disease (AD) experience progressive loss of independence-performing activities of daily living. Identifying interventions to support independence and reduce the economic and psychosocial burden of caregiving for individuals with AD is imperative. The purpose of this analysis was to examine functional disability and caregiver time in individuals with early-stage AD. METHODS: This was a secondary analysis of a randomized controlled trial of 26 weeks of aerobic exercise (AEx) versus stretching and toning (ST). We measured functional dependence using the Disability Assessment for Dementia, informal caregiver time required using the Resources Utilization in Dementia Lite, and cognition using a standard cognitive battery. RESULTS: We saw a stable function in the AEx group compared with a significant decline in the ST group (4%; F = 4.2, P = .04). This was especially evident in more complex, instrumental activities of daily living, with individuals in the AEx group increasing 1% compared with an 8% loss in the ST group over 26 weeks (F = 8.3, P = .006). Change in memory was a significant predictor of declining instrumental activities of daily living performance (r = 0.28, 95% confidence interval = 0.08 ∞, P = .01). Informal caregiver time was not different between the AEx and ST groups. CONCLUSIONS: Our analysis extends recent work by revealing specific benefits for instrumental activities of daily living for individuals in the early stages of AD and supports the value of exercise for individuals with cognitive impairment.
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“Exercise has been documented to improve physical health and well-being (33), to reduce behavioral and psychological symptoms of dementia (BPSD) (34–36), and to enhance performance in the activities of daily living (ADL) (37, 38) in patients with AD or dementia.”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [38]
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Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01058 · Cited by 297
López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101479 · Cited by 152
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79
The Effect of Baseline Patient and Caregiver Mindfulness on Dementia Outcomes
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Metadata
- Authors
- Vidoni, E. D., Perales, J., Alshehri, M., Giles, A.-M., Siengsukon, C. F., & Burns, J. M.
- Affiliations
- University of Kansas (US)
- University of Kansas Alzheimer's Disease Center, Fairway.
- University of Kansas Medical Center (US)
- Wichita State University (US)
- Corresponding author
- Vidoni, Eric D.
- Venue
- Journal of Geriatric Physical Therapy
- Published
- 2019-07
- Volume
- 42
- Issue
- 3
- Pages
- E129-E134
- ISSN
- 1539-8412 (ISSN-L)
- PMC
- PMC6023779
- OpenAlex
- W2776167426
- Cited by
- 61
- References
- 56
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 3 · 2019: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Geriatric Physical Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000001, KL2TR000119, UL1TR002366)
- National Institute on Aging (R01AG033673, R01AG034614, P30AG035982, P30AG072973)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- Alzheimer's disease, aerobic exercise, instrumental activities of daily living, functional dependence, early-stage dementia, informal caregivers, caregiver burden, memory decline, cognitive impairment, exercise intervention
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Disability Evaluation, Female, Humans, Male, Memory, Middle Aged, Time Factors, Exercise, Caregivers, Muscle Stretching Exercises
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