Detection of Basic Drugs (Methamphetamine, Antidepressants, and Nicotine) from Human Hair
Abstract
Human hair contains methamphetamine, amitriptyline, imipramine, nicotine, and their metabolites in some amount, which can be detected by routine toxicological methods. Sometimes, the level of drugs reaches over 100 μg/g. Animal experiments indicate that these drugs are found solely in sections of hair grown after administration of the drugs. The negative stage after the administration of drugs means that the hair section containing drugs has not come out of the hair follicle. Toxicological examination of the hairs may give some clue helping to identify the chronology of the intoxication.
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Nicotine concentrations in the hair of smokers have been reported to be 100 μM.
“Nicotine con- centrations in the hair of smokers has been reported to be 100 ,uM (27, 28).”
From Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. (1986) · cites this paper as [28]
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Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
Barbieri, R. L., Gochberg, J., & Ryan, K. J. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112494 · Cited by 197 · see citing works
- Authors
- Ishiyama, I., Nagai, T., & Toshida, S.
- Affiliations
- Teikyo University (JP)
- Venue
- Journal of Forensic Sciences
- Publisher
- ASTM International
- Published
- 1983-04-01
- Volume
- 28
- Issue
- 2
- Pages
- 380-385
- ISSN
- 0022-1198 (ISSN-L)
- OpenAlex
- W22475263
- Cited by
- 117
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2015: 1 · 2012: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Forensic Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Historical and Scientific Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- hair analysis, methamphetamine, antidepressants, nicotine, amitriptyline, imipramine, drug metabolites, toxicological examination, hair follicle
- MeSH terms
- Amphetamines, Animals, Antidepressive Agents, Tricyclic, Chromatography, Gas, Female, Hair, Humans, Male, Gas Chromatography-Mass Spectrometry, Methamphetamine, Middle Aged, Nicotine, Mass Spectrometry, Staining and Labeling, Substance-Related Disorders, Mice
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