Regional distribution of cocaine in postmortem brain of chronic human cocaine users.
Abstract
We measured concentrations of cocaine and its major metabolites (benzoylecgonine, ecgonine methylester, norcocaine, and cocaethylene) in 15 autopsied brain regions of 14 human chronic cocaine users. Only slight differences were observed in concentrations of cocaine and its metabolites amongst the examined brain areas. Although it is likely that some postmortem redistribution of the drug must have occurred, our data are consistent with the possibility that behaviorally relevant doses of cocaine are widely distributed throughout the brain of humans who use the drug on a chronic basis. Consideration should therefore be given to the possible pharmacological and toxicological actions of cocaine in both striatal and extra-striatal brain areas in human users of the drug.
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Levels of cocaine in postmortem brains of chronic cocaine users with acute intoxications are greater than 100 μM.
“Further, the levels of cocaine in the postmortem brains of chronic cocaine users with acute intoxications have been found to be greater than 100 μM (Kalasinsky et al., 2000).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Kalasinsky et al., 2000
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Chivero, E. T., Liao, K., Niu, F., Tripathi, A., Tian, C., Buch, S., & Hu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00573 · Cited by 69 · see citing works
- Authors
- Kalasinsky, K., Bosy, T., Schmunk, G., Ang, L., Adams, V, Gore, S., Smialek, J., Furukawa, Y., Guttman, M., & Kish, S.
- Affiliations
- Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Division of Forensic Toxicology, Armed Forces Institute of Pathology 1 , Washington, DC .
- Santa Clara County Medical Examiner-Coroner, San Jose, CA and Stanford University 2 , Palo Alto, CA .
- Department of Pathology (Neuropathology), Sunnybrook Hospital 3 , Toronto, Canada .
- Office of the Hillsborough County Medical Examiner 4 , Tampa, FL .
- Office of the Medical Examiner of District 9 5 , Onando, FL .
- University of Maryland 6 Department of Pathology, , Baltimore, MD .
- Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Clarke Division 7 , 250 College Street Toronto, OntarioCanadaM5T 1R8 .
- Venue
- Journal of Forensic Sciences
- Publisher
- ASTM International
- Published
- 2000-09-01
- Volume
- 45
- Issue
- 5
- Pages
- 1041-1048
- ISSN
- 0022-1198
- Cited by
- 44
- References
- 0
- Language
- en
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