Why does depression hurt? Ancestral primary process separation-distress (PANIC/GRIEF) and diminished brain reward (SEEKING) processes in the genesis of depressive affect
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The anti-suicidal potential of buprenorphine is in line with human and animal studies linking suicidal behavior with mental pain and endorphinergic control of the separation distress system.
“The results on the anti-suicidal potential of BUP are instead in line with both human and animal studies that linked suicidal behavior with both mental pain and endorphinergic control of the separation distress system [57].”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [57]
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References 61 · Cited by 207
- Authors
- Panksepp, J., & Watt, D.
- Affiliations
- Washington State University (US)
- Harvard University (US)
- Venue
- Psychiatry: Interpersonal and Biological Processes
- Publisher
- Guilford Publications
- Published
- 2011-03
- Volume
- 74
- Issue
- 1
- Pages
- 5-13
- ISSN
- 0033-2747 (ISSN-L)
- OpenAlex
- W2051458162
- Cited by
- 207
- References
- 61
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 13 · 2023: 9 · 2022: 10 · 2021: 52 · 2020: 7 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 13 · 2013: 16 · 2012: 10
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- depression, brain reward, depressive affect, evolutionary psychology
- MeSH terms
- Affect, Animals, Brain, Buprenorphine, Depression, Disease Models, Animal, Biological Evolution, Grief, Humans, Models, Neurological, Panic, Reward
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