Plasma Membrane Ca2+ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse
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Plasma membrane Ca 2+ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca 2+and Ca 2+excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2−/− knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca 2+extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.
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Ca2+ is rapidly removed from cytoplasm into extracellular space by plasma membrane calcium ATPases; ATP2B2 encodes PMCA2, whose kinetics and Ca2+ affinity make it critical to synaptic function and plasticity especially in Purkinje cell dendritic spines and parvalbumin-positive GABAergic interneurons.
“Ca2+ is rapidly removed from the cytoplasm into the extracellular space by plasma membrane calcium ATPases (PMCAs); the ATP2B2 gene encodes for PMCA2, whose faster kinetic and broader Ca2+ affinity range makes this PMCA critical to synaptic function and plasticity especially in the dendritic spines of Purkinje cells and in parvalbumin-positive gabaergic interneurons [244–246].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [244]
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References 27 · Cited by 59
- Authors
- Empson, R. M., Garside, M. L., & Knöpfel, T.
- Affiliations
- Royal Holloway University of London (GB)
- RIKEN Center for Brain Science (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-04-04
- Volume
- 27
- Issue
- 14
- Pages
- 3753-3758
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672407
- OpenAlex
- W2069227664
- Cited by
- 59
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 7
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Directorate for Biological Sciences
- RIKEN
- RIKEN Brain Science Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- PMCA2, short-term plasticity, cerebellum, cytosolic calcium regulation, cerebellar development
- MeSH terms
- Animals, Cerebellum, Female, Isoenzymes, Male, Neuronal Plasticity, Purkinje Cells, Reaction Time, Synapses, Mice, Knockout, Muscle Fibers, Fast-Twitch, Mice, Plasma Membrane Calcium-Transporting ATPases
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