Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum
Open accessAbstract
Slow (<0.1 Hz), spontaneous fluctuations in the functional magnetic resonance imaging blood oxygen level-dependent (BOLD) signal have been shown to exhibit phase coherence within functionally related areas of the brain. Surprisingly, this phenomenon appears to transcend levels of consciousness. The genesis of coherent BOLD fluctuations remains to be fully explained. We present a resting state functional connectivity study of a 6-year-old child with a radiologically normal brain imaged both before and after complete section of the corpus callosum for the treatment of intractable epilepsy. Postoperatively, there was a striking loss of interhemispheric BOLD correlations with preserved intrahemispheric correlations. These unique data provide important insights into the relationship between connectional anatomy and functional organization of the human brain. Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders.
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Interhemispheric resting state functional connectivity is almost completely abolished directly after callosotomy.
“Interhemispheric resting state functional connectivity is diminished in cases of callosal agenesis (20) and is almost completely abolished directly after callosotomy (21,22).”
From Relation Between Structural and Functional Connectivity in Major Depressive Disorder (2013) · cites this paper as [21]
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References 40 · Cited by 296
Research works printed but not linked: 2
- Amaral DG, Price JL, Pitkanen A, Carmichael ST (1992) Anatomical orga- nization of the primate amygdaloid complex. New York: Wiley.
- Jones EG (2007) The thalamus. Cambridge, UK: Cambridge UP.
- Authors
- Johnston, J. M., Vaishnavi, S. N., Smyth, M. D., Zhang, D., He, B. J., Zempel, J. M., Shimony, J. S., Snyder, A. Z., & Raichle, M. E.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-06-18
- Volume
- 28
- Issue
- 25
- Pages
- 6453-6458
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2738991
- OpenAlex
- W2071808690
- Cited by
- 296
- References
- 40
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 11 · 2019: 22 · 2018: 12 · 2017: 18 · 2016: 14 · 2015: 22 · 2014: 21 · 2013: 38 · 2012: 13
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS06833)
- National Institute of Neurological Disorders and Stroke (P50NS006833, NS 06833)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- corpus callosotomy, corpus callosum, interhemispheric functional connectivity, resting-state functional connectivity, BOLD signal fluctuations, phase coherence, drug-resistant epilepsy, pediatric epilepsy, hemispheric lateralization, large-scale brain organization
- MeSH terms
- Child, Corpus Callosum, Epilepsy, Humans, Functional Laterality, Magnetic Resonance Imaging, Male
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