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Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1
Open accessAbstract
To probe for the role of the L1 cell surface glycoprotein during neurite outgrowth and fasciculation in the early postnatal mouse cerebellar cortex, a microexplant culture system was used. Fasciculation of neurites was reduced in the presence of antigen- binding fragments (Fab) of poly- and monoclonal L1 antibodies, as compared to untreated controls. In addition, speed of neurite outgrowth was enhanced in the presence of antibodies. Migration of cell bodies of small neurons was also significantly increased. Very similar effects on these outgrowth parameters were observed with Fab fragments from poly- and monoclonal neural cell adhesion molecule (N-CAM) antibodies. Antibodies from preimmune sera had no effect. These findings suggest that L1 antigen not only plays a role in adhesion of isolated neural cell bodies and migration of granule cell neurons in the early postnatal mouse cerebellar cortex (Lindner et al., 1983; Rathjen and Schachner, 1984), but also in neurite outgrowth and fasciculation.
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Cited by
The Neural Cell Adhesion Molecule (NCAM) as a Regulator of Cell-Cell Interactions
Rutishauser, U., Acheson, A., Hall, A. K., Mann, D. M., & Sunshine, J. (1988) · Science · doi:10.1126/science.3281256 · Cited by 787
Legouis, R., Hardelin, J.-P., Levilliers, J., Claverie, J.-M., Compain, S., Wunderle, V., Millasseau, P., Le Paslier, D., Cohen, D., & Caterina, D. (1991) · Cell · doi:10.1016/0092-8674(91)90193-3 · Cited by 678
Furley, A. J., Morton, S. B., Manalo, D., Karagogeos, D., Dodd, J., & Jessell, T. M. (1990) · Cell · doi:10.1016/0092-8674(90)90223-2 · Cited by 567
Disruption of the mouse L1 gene leads to malformations of the nervous system
Dahme, M., Bartsch, U., Martini, R., Anliker, B., Schachner, M., & Mantei, N. (1997) · Nature Genetics · doi:10.1038/ng1197-346 · Cited by 489
Self-citationAdhesion molecules and the hierarchy of neural development
Jessell, T. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90204-8 · Cited by 425
Metadata
- Authors
- Fischer, G., Kunemund, V, & Schachner, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1986-02-01
- Volume
- 6
- Issue
- 2
- Pages
- 605-612
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1582166679
- Cited by
- 263
- References
- 0
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1. https://app.cochat.ai/papers/10.1523/jneurosci.06-02-00605.1986
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- Fischer, G., Kunemund, V, & Schachner, M. (1986). Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.06-02-00605.1986
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