Induction of long-term memory by exposure to novelty requires protein synthesis: evidence for a behavioral tagging
Open accessAbstract
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memory-promoting effect caused by novelty depends on activation of dopamine D1/D5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace.
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Exploration of a novel environment can make a memory for a weak event more persistent.
“exploration of a novel environment can make a memory for a ‘weak’ event more persistent [70–72].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [70]
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References 42 · Cited by 370
- Authors
- Moncada, D., & Viola, H.
- Affiliations
- Universidad de Buenos Aires (AR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-07-11
- Volume
- 27
- Issue
- 28
- Pages
- 7476-7481
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672624
- OpenAlex
- W2041915527
- Cited by
- 370
- References
- 42
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 41 · 2023: 20 · 2022: 25 · 2021: 26 · 2020: 23 · 2019: 16 · 2018: 29 · 2017: 19 · 2016: 26 · 2015: 20 · 2014: 25 · 2013: 14 · 2012: 8
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
- Funders
- Fundación Antorchas
- Universidad de Buenos Aires
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- long-term memory, novelty, synaptic tagging and capture, passive avoidance, memory consolidation, dopamine D1/D5 receptors, protein synthesis, dorsal hippocampus, synaptic plasticity
- MeSH terms
- Animals, Avoidance Learning, Exploratory Behavior, Hippocampus, Male, Memory, Nerve Tissue Proteins, Neuronal Plasticity, Time Factors, Rats, Wistar, Receptors, Dopamine D1, Receptors, Dopamine D5, Rats
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