Halothane blocks low-voltage-activated calcium current in rat sensory neurons
Open accessAbstract
Although volatile anesthetic agents have been used clinically for many years, the mechanisms by which they act on the nervous system to produce anesthesia are not known. A possible site of action is the voltage-gated calcium-selective channel (Krnjevic and Puil, 1988). Accordingly, the action of the halogenated alkane anesthetic halothane on voltage-dependent Ca currents in neonatal rat sensory neurons was examined using whole-cell patch-clamp recordings. Halothane reversibly reduced the low-voltage-activated Ca current with an EC50 of about 100 microM. Similar effects were seen using a halogenated ether anesthetic (isoflurane) and in sensory neurons from adult rats. At higher concentrations, both halothane and isoflurane reduced the high-voltage- activated Ca current. Because low-voltage-activated Ca current. Because low-voltage-activated Ca current has been postulated to be involved in the control of neuronal excitability and bursting (Llinas, 1988), this block may explain some of the clinical actions of volatile anesthetics.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
T-type calcium channels are important for cell excitability, are expressed in mammalian brain including thalamus, and are especially sensitive to clinical doses of volatile anesthetics.
“T-type calcium receptors play an important role in cell excitability, are expressed in the mammalian brain in many regions (including the thalamus), and are especially sensitive to clinical doses of volatile anesthetics [65].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 29 · Cited by 69
Research works printed but not linked: 1
- Herrington J,Stem RC, Evers AS. Lingle CJ (I 990) HaIothane reduces calcium currents in clonal (GH,) pituitary cells. New York Academy of Sciences Conference on Molecular and Cellular Mechanisms of Alcohol and Anesthetics, Abstract W-6.
- Authors
- Takenoshita, M., & Steinbach, J.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Takenoshita, M
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1991-05-01
- Volume
- 11
- Issue
- 5
- Pages
- 1404-1412
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6575308
- OpenAlex
- W1931208730
- Cited by
- 69
- References
- 29
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 2 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS022356, NS 22356)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- halothane, isoflurane, volatile anesthetics, low-voltage-activated calcium current, high-voltage-activated calcium current, voltage-gated calcium channels, sensory neurons, neuronal excitability, anesthetic mechanisms, halogenated ethers
- MeSH terms
- Aging, Animals, Animals, Newborn, Evoked Potentials, Ganglia, Spinal, Halothane, Isoflurane, Kinetics, Membrane Potentials, Neurons, Afferent, Rats, Inbred Strains, Calcium Channels, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
