The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
NGF improves spatial memory in aged rodents as a function of age
Open accessAbstract
Aged rats were tested for place navigation in a circular water maze for spatial memory ability at 18 and 30 months of age; 45% of the 18-month- old rats displayed impaired place navigation performance relative to young control rats, while essentially all of the 30-month-old rats were impaired. The aged impaired rats were retested twice during NGF or vehicle infusion in the right lateral ventricle. In the 18-month-old group, NGF-infused rats showed improved retention of previously acquired place navigation performance and improved spatial acuity over the former platform site when the invisible platform was removed. NGF infusion also had a significant effect in the much more severely impaired 30-month-old rats: while the vehicle-infused aged rats showed a progressive decline in the performance between the first and second test weeks, the performance of the NGF-infused rats remained stable throughout the infusion period. The interpretation of these effects in the oldest animals, however, was confounded by a progressive decline in swim speed seen in the vehicle-infused animals. The 30-month-old vehicle-infused control rats showed a significant cell loss and cell shrinkage relative to the young control rats in the septal/diagonal band area, the striatum, and the nucleus basalis as assessed by NGF- receptor (NGFr) and ChAT double-label immunocytochemistry. A significant increase in the size but not in the number of cells was observed on the side of the NGF infusion in the 30-month-old NGF- infused rats.
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Citations
Cites
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,450
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Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death
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Cited by
Applications of the Morris water maze in the study of learning and memory
D’Hooge, R., & De Deyn, P. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,040
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 666
The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease
Schliebs, R., & Arendt, T. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0579-2 · Cited by 530
Trophic effects of purines in neurons and glial cells
Rathbone, M. P., Middlemiss, P. J., Gysbers, J. W., Andrew, C., Herman, M. A. R., Reed, J. K., Ciccarelli, R., Di Iorio, P., & Caciagli, F. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00017-9 · Cited by 398
Neurocognitive aging: prior memories hinder new hippocampal encoding
Wilson, I. A., Gallagher, M., Eichenbaum, H., & Tanila, H. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.002 · Cited by 345
Metadata
- Authors
- Fischer, W., Bjorklund, A., Chen, K., & Gage, F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1991-07-01
- Volume
- 11
- Issue
- 7
- Pages
- 1889-1906
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1647778121
- Cited by
- 259
- References
- 28
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fischer, W., Bjorklund, A., Chen, K., & Gage, F. (1991). NGF improves spatial memory in aged rodents as a function of age. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.11-07-01889.1991
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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