Functional properties and projections of neurons in the medial amygdala
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The medial nucleus of the amygdala (MeA) plays a key role in innate emotional behaviors by relaying olfactory information to hypothalamic nuclei involved in reproduction and defense. However, little is known about the neuronal components of this region or their role in the olfactory-processing circuitry of the amygdala. Here, we have characterized neurons in the posteroventral division of the medial amygdala (MePV) using the GAD67-GFP mouse. Based on their electrophysiological properties and GABA expression, unsupervised cluster analysis divided MePV neurons into three types of GABAergic (Types 1-3) and two non-GABAergic cells (Types I and II). All cell types received olfactory synaptic input from the accessory olfactory bulb and, with the exception of Type 2 GABAergic neurons, sent projections to both reproductive and defensive hypothalamic nuclei. Type 2 GABAergic cells formed a chemically and electrically interconnected network of local circuit inhibitory interneurons that resembled neurogliaform cells of the piriform cortex and provided feedforward inhibition of the olfactory-processing circuitry of the MeA. These findings provide a description of the cellular organization and connectivity of the MePV and further our understanding of amygdala circuits involved in olfactory processing and innate emotions.
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AOB mitral cells project primarily to the medial amygdala, which in turn connects to hypothalamic regions associated with the control of social behaviors.
“AOB mitral cells project primarily to the medial amygdala (MeA), which in turn connects to hypothalamic regions associated with the control of social behaviors (Keshavarzi et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Keshavarzi et al., 2014
The MeApd comprises GABAergic and glutamatergic neurons at an approximate ratio of 2:1, with GABAergic neurons representing the major population of projection neurons driving social responses.
“The MeApd comprises GABAergic and glutamatergic neurons at an approximate ratio of 2:1, with GABAergic neurons representing the major population of projection neurons driving social responses (Choi et al., 2005; Hong et al., 2014; Keshavarzi et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Keshavarzi et al., 2014
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References 71 · Cited by 176
Research works printed but not linked: 1
- McDonald AJ (1992) Cell types and intrinsic connections of the amygdala. In: The amygdala: neurobiological aspects of emotion, memory and men- tal dysfunction (Aggleton JP, ed), pp 67-96. New York: Wiley.
- Authors
- Keshavarzi, S., Sullivan, R. K. P., Ianno, D. J., & Sah, P.
- Affiliations
- The University of Queensland (AU)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-06-25
- Volume
- 34
- Issue
- 26
- Pages
- 8699-8715
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6608208
- OpenAlex
- W2031091121
- Cited by
- 176
- References
- 71
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 22 · 2023: 18 · 2022: 17 · 2021: 20 · 2020: 25 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 15 · 2015: 11
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- medial amygdala, GABAergic neurons, olfactory processing, accessory olfactory bulb, hypothalamic projections, reproductive behavior, defensive behavior, neurogliaform cells, feedforward inhibition, neuronal cell types, electrophysiological properties
- MeSH terms
- Amygdala, Animals, Male, Neurons, Olfactory Bulb, Olfactory Pathways, Mice, GABAergic Neurons
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