The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS
Open accessAbstract
A conspicuous correlate of the developmental transformation of axonal growth cones to synaptic terminals is a marked increase in synthesis and axonal transport of a methionine-rich, acidic polypeptide of approximately 25 kDa. This polypeptide, designated “super protein” (SuP), is the most prominent species among methionine-labeled proteins conveyed by rapid axonal transport in mature CNS and PNS neurons of warm- and cold-blooded vertebrates. We show here that SuP is identical to SNAP-25, a highly conserved synaptic protein of known primary structure, by immunoprecipitation with anti-SNAP-25 antiserum of SuP labeled with 35S-methionine and transported by retinal ganglion cells of rat and cat. In addition, we show that SNAP-25/SuP is the most prominent species among retinal polypeptides that incorporate 3H- palmitate in vivo, that it is fatty acylated through a hydroxylamine- labile, thioester bond, and that palmitoylated SNAP-25/SuP is axonally transported. Thus, SNAP-25/SuP is a rapidly transported constituent of the presynaptic apparatus and a major neuronal substrate for long-chain fatty acylation.
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Metadata
- Authors
- Hess, D., Slater, T., Wilson, M., & Skene, J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-12-01
- Volume
- 12
- Issue
- 12
- Pages
- 4634-4641
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2114647945
- Cited by
- 309
- References
- 37
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hess, D., Slater, T., Wilson, M., & Skene, J. (1992). The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.12-12-04634.1992
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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