From the neuroscience of individual variability to climate change
Open accessAbstract
Years of basic neuroscience on the modulation of the small circuits found in the crustacean stomatogastric ganglion have led us to study the effects of temperature on the motor patterns produced by the stomatogastric ganglion. While the impetus for this work was the study of individual variability in the parameters determining intrinsic and synaptic conductances, we are confronting substantial fluctuations in the stability of the networks to extreme temperature; these may correlate with changes in ocean temperature. Interestingly, when studied under control conditions, these wild-caught animals appear to be unchanged, but it is only when challenged by extreme temperatures that we reveal the consequences of warming oceans.
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Biological systems that appear similar when unperturbed may show hidden 'cryptic' changes that are variable but only revealed when perturbed.
“may show hidden 'cryptic' changes that are variable but only revealed when perturbed [44,45]”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [45]
The Figure 3 section says similar baseline activity can hide cryptic animal-to-animal variability that becomes visible when networks are perturbed. But it also says that measuring individual circuit parameters can reveal that variability, so the claim’s “only revealed when perturbed” is too exclusive. No page number was available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSeveral years later, crab preparations retained robust pyloric rhythms at temperatures as high as 35°C.
“Several years later, preparations retained robust pyloric rhythms at temperatures as high as 35 • C [45].”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [45]
The crash temperatures changed yearly as the mean ocean temperatures fluctuated.
“Eventually it became clear that the crash temperatures changed yearly, as the mean ocean temperatures fluctuated [45].”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [45]
Biological systems that appear similar when unperturbed might respond to perturbations in unanticipated different ways.
“biological systems that appear similar when unperturbed might respond to perturbations in unanticipated different ways [43-45]”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [45]
Biological systems are degenerate.
“Because biological systems are degenerate”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [45]
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Cites
How multiple conductances determine electrophysiological properties in a multicompartment model
Taylor, A. L., Goaillard, J.-M., & Marder, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4438-08.2009 · Cited by 202 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Gorur-Shandilya S, Cronin EM, Schneider AC, Haddad SA, Rosenbaum P, Bucher D, Nadim F, Marder E (2021) Mapping circuit dynamics during function and dysfunction. bioRxiv 451370. doi: 10.1101/2021.07.06. 451370. · DOI
Cited by
Sorted by citations
A biophysical perspective on the resilience of neuronal excitability across timescales
Marom, S., & Marder, E. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00730-9 · Cited by 59 · see citing works
Self-citationA feature and not a bug: Replication failures can lead to new biology
Marder, E. (2026) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2026.103268
Self-citation
- Authors
- Marder, E., & Rue, M. C. P.
- Affiliations
- Brandeis University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2021-11-09
- Volume
- 41
- Issue
- 50
- Pages
- 10213-10221
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC8672684
- OpenAlex
- W3212431537
- Cited by
- 50
- References
- 1
- Citations by year
- 2026: 11 · 2025: 6 · 2024: 18 · 2023: 10 · 2022: 5
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Neurological Disorders and Stroke (NS 097343, F31 NS 113383)
- HHS | NIH | National Institute of Mental Health (MH 46742)
- Topics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- stomatogastric ganglion, interindividual variability, synaptic conductance, network stability, ocean warming, climate change, wild-caught animals
- MeSH terms
- Animals, Brachyura, Nephropidae, Models, Neurological, Neurosciences, Climate Change
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