Neuronal activity within the nucleus basalis and conditioned neocortical electroencephalographic activation
Open accessAbstract
The relationship between neuronal activity within the nucleus basalis (NB) and conditioned neocortical EEG activation was investigated in New Zealand rabbits during Pavlovian differential conditioning. Twenty-seven of 56 neurons recorded in conditioned animals demonstrated a significantly greater change in activity to a tone (CS+) that predicted the occurrence of a mildly aversive unconditioned stimulus when compared to a tone (CS-) that did not. Twenty-four of these 27 neurons demonstrated a significant increase in activity to the CS+ compared to the CS-, while the remaining three neurons demonstrated a significant decrease in activity to the CS+ compared to the CS-. In 24 of these 27 neurons (89%) these changes in neuronal activity during CS presentations correlated significantly with a decrease in the power of delta activity in the EEG. In addition, 13 of these 24 neurons (54%) demonstrated significant correlations between neuronal activity and the power of delta activity during CS-free periods. In experimentally naive animals, the activity of 10 of 22 neurons (45%) recorded within the region of the NB correlated with the power of delta activity in the EEG during stimulus-free periods. These results complement a growing body of evidence and provide strong support for the hypothesis that the NB contributes to neocortical activation in the conscious animal.
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Cholinergic cells projecting to the amygdala exhibit high firing rates.
“Cholinergic cells projecting to the amygdala exhibit high firing rates (Whalen et al., 1994)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Whalen et al., 1994
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References 52 · Cited by 87
Research works printed but not linked: 1
- Riekkinen PJ, Riekkinen P Jr, Paljarvi L, Soininen H, Halonen T, Reinikainen K, Partanen J (1990) Relationship between cholin- ergic pathology and EEG slowing. In: Key topics in brain research. Alzheimer's disease: epidemiology, neuropathology, neurochemistry, clinics (Riederen P, Beckman H, eds), pp 437-445. Berlin: Springer.
- Authors
- Whalen, P., Kapp, B., & Pascoe, J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-03-01
- Volume
- 14
- Issue
- 3
- Pages
- 1623-1633
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577570
- OpenAlex
- W1503776348
- Cited by
- 87
- References
- 52
- Citations by year
- 2023: 2 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 5 · 2014: 3 · 2012: 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9010760)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus basalis of Meynert, neuronal activity, conditioned stimulus, unconditioned stimulus, neocortex, rabbits, aversive conditioning
- MeSH terms
- Acoustic Stimulation, Animals, Basal Ganglia, Cerebral Cortex, Conditioning, Classical, Electroencephalography, Neurons, Rabbits, Reference Values
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