The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain
Open accessAbstract
Multiple voltage-gated potassium (K) channel gene products are likely to be involved in regulating neuronal excitability of any single neuron in the mammalian brain. Here we show that two closely related voltage- gated K channel proteins, mKv1.1 and mKv1.2, are present in multiple subcellular locations including cell somata, juxta-paranodal regions of myelinated axons, synaptic terminals, unmyelinated axons, specialized junctions among axons, and proximal dendrites. Staining patterns of the two channel polypeptides overlap in some areas of the brain, yet each has a unique pattern of expression. For example, in the hippocampus, both mKv1.1 and mKv1.2 proteins are present in axons, often near or at synaptic terminals in the middle molecular layer of the dentate gyrus, while only mKv1.1 is detected in axons and synaptic terminals in the hilar/CA3 region. In the cerebellum, both channel proteins are localized to axon terminals and specialized junctions among axons in the plexus region of basket cells. Strong differential staining is observed in the olfactory bulb, where mKv1.2 is localized to cell somata and axons, as well as to proximal dendrites of the mitral cells. This overlapping yet differential pattern of expression and specific subcellular localization may contribute to the unique profile of excitability displayed by a particular neuron.
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1 retracted
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Wang, H., Kunkel, D. D., Martin, T. M., Schwartzkroin, P. A., & Tempel, B. L. (1993) · Nature · doi:10.1038/365075a0 · Cited by 647
Self-citationCerebellar cortex, cytology and organization
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Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel
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Cited by
A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels
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Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies
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Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy
Li, K.-X., Lu, Y.-M., Xu, Z.-H., Zhang, J., Zhu, J.-M., Zhang, J.-M., Cao, S.-X., Chen, X.-J., Chen, Z., Luo, J.-H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3006 · Cited by 173
Metadata
- Authors
- Wang, H., Kunkel, D., Schwartzkroin, P., & Tempel, B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-08-01
- Volume
- 14
- Issue
- 8
- Pages
- 4588-4599
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1935182457
- Cited by
- 388
- References
- 24
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, H., Kunkel, D., Schwartzkroin, P., & Tempel, B. (1994). Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.14-08-04588.1994
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