GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits

Kelsch, Wolfgang; Li, Zhijun; Eliava, Marina; Goengrich, Christina; Monyer, Hannah

doi:10.1523/jneurosci.1459-12.2012

GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits

In the developing telencephalon, NMDA receptors (NMDARs) are composed of GluN1 and GluN2B subunits. These “young” NMDARs set a brake on synapse recruitment in neurons of the neonatal cortex. The functional role of GluN2B for synapse maturation of adult-born granule cells (GCs) in the olfactory bu…