The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells
Open accessAbstract
Early-life adversity is associated with a broad scope of life-long health and behavioral disorders. Particularly critical is the role of the mother. A possible mechanism is that these effects are mediated by "epigenetic" mechanisms. Studies in rodents suggest a causal relationship between early-life adversity and changes in DNA methylation in several "candidate genes" in the brain. This study examines whether randomized differential rearing (maternal vs surrogate-peer rearing) of rhesus macaques is associated with differential methylation in early adulthood. The data presented here show that differential rearing leads to differential DNA methylation in both prefrontal cortex and T cells. These differentially methylated promoters tend to cluster by both chromosomal region and gene function. The broad impact of maternal rearing on DNA methylation in both the brain and T cells supports the hypothesis that the response to early-life adversity is system-wide and genome-wide and persists to adulthood. Our data also point to the feasibility of studying the impact of the social environment in peripheral T-cell DNA methylation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a comparison of epigenome-wide blood and brain DNA methylation patterns in differentially reared rhesus macaques, a considerable functional overlap was observed in DNA methylation profiles in T lymphocytes and prefrontal tissue.
“In a comparison of epigenome-wide blood and brain DNA methylation patterns in differentially reared rhesus macaques, a considerable functional overlap was observed in DNA methylation profiles in T lymphocytes and prefrontal tissue (Provencal et al., 2012).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Provencal et al., 2012
Recent research has demonstrated an association between peripheral and central measures of methylation.
“recent research has demonstrated an association between peripheral and central measures of methylation (Provençal et al., 2012).”
From Associations Between Early Life Stress and Gene Methylation in Children (2015) · cites this paper as Provençal et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 95 · Cited by 312
- Authors
- Provençal, N., Suderman, M. J., Guillemin, C., Massart, R., Ruggiero, A., Wang, D., Bennett, A. J., Pierre, P. J., Friedman, D. P., Côté, S. M., Hallett, M., Tremblay, R. E., Suomi, S. J., & Szyf, M.
- Affiliations
- McGill University (CA)
- National Institutes of Health (US)
- Wake Forest University Health Sciences (US)
- University of Wisconsin–Madison (US)
- University College Dublin (IE)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-10-31
- Volume
- 32
- Issue
- 44
- Pages
- 15626-15642
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3490439
- OpenAlex
- W2092363037
- Cited by
- 312
- References
- 95
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 15 · 2020: 26 · 2019: 18 · 2018: 25 · 2017: 31 · 2016: 49 · 2015: 36 · 2014: 57 · 2013: 25 · 2012: 1
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institute for Advanced Research
- McGill University
- National Institutes of Health
- Canadian Institutes of Health Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD001106)
- NHLBI Division of Intramural Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- maternal care, childhood adversity, DNA methylation, epigenetics, rhesus monkeys, prefrontal cortex, T cells, differential rearing, social environment, early adulthood
- MeSH terms
- Animals, Base Sequence, Chromosomes, Macaca mulatta, Male, Maternal Deprivation, Molecular Sequence Data, RNA, Social Environment, T-Lymphocytes, Prefrontal Cortex, In Situ Hybridization, DNA, Complementary, DNA Methylation, Microarray Analysis, Immunoprecipitation, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
