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Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus in vitro
Open accessAbstract
The protein kinase C activator phorbol 12,13-dibutyrate (0.5 microM, PDBu) and the protein kinase A activator forskolin (20 microM) each increased evoked monosynaptic inhibitory postsynaptic current (IPSC) amplitude, without affecting its reversal potential, and increased the frequency of miniature IPSCs (mIPSCs), without affecting their amplitude or kinetics, as assessed with whole-cell recording form CA3 pyramidal cells in hippocampal slice cultures. The effects of forskolin and PDBu on both evoked IPSC amplitude and mIPSC frequency were additive and were antagonized by inhibitors of protein kinases A and C, respectively. The kinase activator-induced increases in mIPSC frequency were quantitatively comparable to the increases in evoked IPSC amplitude. The increases in mIPSC frequency were not attenuated by the voltage-dependent calcium channel blocker Cd2+ (100 microM). We conclude that stimulation of protein kinases A and C potentiates hippocampal inhibitory synaptic transmission through independent presynaptic mechanisms of action. Kinase-induced potentiation of spontaneous release does not require modulation of axon terminal Ca2+ channels. This mechanism may also contribute substantially to the potentiation of evoked release.
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Citations
Cites
Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus
Hopkins, W. F., & Johnston, D. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.2.667 · Cited by 310
Cited by
Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 631
How opioids inhibit GABA-mediated neurotransmission
Vaughan, C. W., Ingram, S. L., Connor, M. A., & Christie, M. J. (1997) · Nature · doi:10.1038/37610 · Cited by 507
Chen, K., Baram, T. Z., & Soltesz, I. (1999) · Nature Medicine · doi:10.1038/11330 · Cited by 283
Astroglial Excitability and Gliotransmission: An Appraisal of Ca 2+ as a Signalling Route
Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A., & Parpura, V. (2012) · ASN Neuro · doi:10.1042/an20110061 · Cited by 264
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1α
Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Südhof, T. C., & Castillo, P. E. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.020 · Cited by 261
Metadata
- Authors
- Capogna, M., Gahwiler, B., & Thompson, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-02-01
- Volume
- 15
- Issue
- 2
- Pages
- 1249-1260
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2142122391
- Cited by
- 192
- References
- 1
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Capogna, M., Gahwiler, B., & Thompson, S. (1995). Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus in vitro. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.15-02-01249.1995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
