The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine
Open accessAbstract
Microdialysis in behaving animals was used to concomitantly characterize the dopamine and 5-HT responses in the caudate and the norepinephrine response in the hippocampus to the D- and L-isomers of amphetamine and methamphetamine. Doses of all four drugs which promoted similar stereotypy responses produced a D-amphetamine-like response profile of dopamine and dopamine metabolites, suggesting that all these drugs interact with dopamine systems to facilitate the release of transmitter. However, in contrast to the similar behavioral profiles, the magnitude of the dopamine responses diverged significantly. In addition, all four drugs increased extracellular norepinephrine and 5-HT, but the relative responses differed markedly from dopamine and from each other. The contrasting structure-activity relationships for these drugs likely reflect their differential potency at the various neuronal uptake transporters in promoting either transmitter release, and/or uptake blockade. In addition, the interaction of each drug at the vesicular transporters, as well as the availability of a cytoplasmic pool of transmitter likely also contribute to the neurotransmitter response. Because of the particularly divergent transmitter response profiles exhibited by L-methamphetamine, its behavioral and neurotransmitter effects were characterized over a more extended range of doses. Although the duration of the increase in extracellular dopamine was clearly proportional to dose, the dose-dependent increases in the magnitude of the dopamine response did not parallel the behavioral profiles. The results of these studies indicate that, while the dopamine, norepinephrine and 5-HT responses to these drugs probably contribute to the expression of stimulant-induced behaviors, simple relationships between the neurotransmitter responses and the behavioral profiles were not evident.
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“AMP increases the synaptic levels of monoamines (dopamine, noradrenaline and serotonin) by increasing their release through a reversal of the monoamine transporters, primarily the catecholamine transporters (see Fleckenstein et al., 2007; Hutson et al., 2014, for review; Kuczenski et al., 1995; Sulzer et al., 2005).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Kuczenski et al., 1995
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Zetterström, T., Sharp, T., Marsden, C. A., & Ungerstedt, U. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00893.x · Cited by 616
Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model.
Fischer, J. F., & Cho, A. K. (1979) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31549-1 · Cited by 443
Self-citationDetermination of Brain Interstitial Concentrations by Microdialysis
Benveniste, H., Hansen, A. J., & Ottosen, N. S. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07252.x · Cited by 403
Kuczenski, R. T., & Segal, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02051.1989 · Cited by 398
Self-citationSulzer, D., & Rayport, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90339-h · Cited by 389
Heikkila, R. E., Orlansky, H., Mytilineou, C., & Cohen, G. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30227-2 · Cited by 220
Berger, U. V., Gu, X. F., & Azmitia, E. C. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90023-w · Cited by 199
Segal, D. S., & Kuczenski, R. (1987) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39192-5 · Cited by 177
Self-citationSampling considerations for on-line microbore liquid chromatography of brain dialysate
Wages, S. A., Church, W. H., & Justice, J. B. (1986) · Analytical Chemistry · doi:10.1021/ac00121a012 · Cited by 172
Globus, M. Y. ‐., Busto, R., Dietrich, W. D., Martinez, E., Valdés, I., & Ginsberg, M. D. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.123 · Cited by 165
Research works printed but not linked: 1
- Cole SO (1978) Brain mechanisms ofamohetamine-induced anorexia. locomdtion, And stereotypy: a review. fieurosci Biobehav Rev 2:891 100.
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Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,360
Winstanley, C. A., Eagle, D. M., & Robbins, T. W. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.01.001 · Cited by 893
Amphetamine, past and present – a pharmacological and clinical perspective
Heal, D. J., Smith, S. L., Gosden, J., & Nutt, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113482532 · Cited by 653
Neuroadaptations involved in amphetamine and cocaine addiction
White, F. J., & Kalivas, P. W. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00072-6 · Cited by 513
Metadata
- Authors
- Kuczenski, R., Segal, D., Cho, A., & Melega, W.
- Affiliations
- UC San Diego Health System (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-02-01
- Volume
- 15
- Issue
- 2
- Pages
- 1308-1317
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577819
- OpenAlex
- W1934404972
- Cited by
- 376
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 11 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 9 · 2015: 9 · 2014: 24 · 2013: 18 · 2012: 22
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da002411-13, 5r01da004157-14)
- U.S. Public Health Service
- National Institute on Drug Abuse (DA-01568, DA 02411, DA04157, R01DA001568)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- methamphetamine, d-amphetamine, stereotypy, dopamine release, noradrenaline release, serotonin release, caudate nucleus, hippocampus, vesicular transporters, structure-activity relationship, microdialysis
- MeSH terms
- Amphetamine, Animals, Behavior, Animal, Caudate Nucleus, Dopamine, Hippocampus, Methamphetamine, Norepinephrine, Serotonin, Stereoisomerism, Stereotyped Behavior, Microdialysis, Neurotransmitter Agents, Rats
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