Dopaminergic Mechanisms in Actions and Habits: Figure 1.
Open accessAbstract
Recent studies suggest new ways to interpret dopaminergic actions in goal-directed performance and habitual responding. In the early stages of learning dopamine plays an essential role, but with extended training dopamine appears to play a decreasing role in response expression. Experimental manipulation of dopamine levels alters the correlation of cortical and striatal neural activity in behaving animals, and these dopamine-dependent changes in corticostriatal correlations may be reflected in changes in action selection in the basal ganglia. Consistent with this hypothesis, changes in dopamine signaling brought about by sensitization with amphetamine mimic the transition from goal-directed to habit-based instrumental performance. At the cellular level, dopamine-dependent synaptic plasticity may be important initially, and subsequently lead to more persistent changes that no longer require dopamine. The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research.
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Higher levels of dopamine release promote habit formation in the basal ganglia.
“Higher levels of dopamine release also promote habit formation in the basal ganglia87.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [87]
The section “Increasing dopaminergic activity accelerates habit formation” reports that amphetamine sensitization accelerated the shift to habitual responding in rats. But it does not establish that higher dopamine release specifically within the basal ganglia caused that shift; the Abstract says the locus of dopamine’s actions remains under investigation (page numbers unavailable). (LLM, conf=0.84)
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References 31 · Cited by 271
Research works printed but not linked: 2
- Carelli RM, Wolske M, West MO (1997) Loss of lever press-related firing of rat striatal forelimb neurons after repeated sessions in a lever pressing task. J Neurosci 17:1804 -1814.
- Wickens JR, Kotter R (1995) Cellular models of reinforcement. In: Models of information processing in the basal ganglia (Houk JC, Davis JL, Beiser DG, eds), pp 187-214. Cambridge, MA: MIT.
- Authors
- Wickens, J. R., Horvitz, J. C., Costa, R. M., & Killcross, S.
- Affiliations
- Okinawa Institute of Science and Technology Graduate University (JP)
- Boston College (US)
- National Institutes of Health (US)
- Cardiff University (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 31
- Pages
- 8181-8183
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673057
- OpenAlex
- W1983398462
- Cited by
- 271
- References
- 31
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 14 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 30 · 2013: 16 · 2012: 19
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine, goal-directed behavior, habit formation, operant conditioning, corticostriatal circuits, basal ganglia, action selection, amphetamine sensitization, synaptic plasticity, striatum, prefrontal cortex
- MeSH terms
- Animals, Cerebral Cortex, Corpus Striatum, Dopamine, Habits, Humans, Nerve Net, Neuronal Plasticity, Receptors, Dopamine
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