Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

Zhang, Fangyi; Eckman, Chris; Younkin, Steven; Hsiao, Karen K.; Iadecola, Costantino

doi:10.1523/jneurosci.17-20-07655.1997

Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

We studied the role of the amyloid precursor protein (APP) in ischemic brain damage using transgenic mice overexpressing APP. The middle cerebral artery (MCA) was occluded in FVB/N mice expressing APP 695 .SWE (Swedish mutation) and in nontransgenic littermates. Infarct volume (cubic millimeters)…