The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan
Open accessAbstract
Chondroitin sulfate proteoglycans (CSPGs) are implicated in the regulation of axonal growth. We previously reported that the neurite-promoting activity of laminin is inhibited by association with a Schwann cell-derived CSPG and that endoneurial laminin may be inhibited by this CSPG as well [Zuo J, Hernandez YJ, Muir D (1998) Chondroitin sulfate proteoglycan with neurite-inhibiting activity is upregulated after peripheral nerve injury. J Neurobiol 34:41-54]. Mechanisms regulating axonal growth were studied by using an in vitro bioassay in which regenerating embryonic dorsal root ganglionic neurons (DRGn) were grown on sections of normal adult nerve. DRGn achieved slow neuritic growth on sections of normal nerve, which was reduced significantly by treatment with metalloproteinase inhibitors. Similar results were obtained on a synthetic substratum composed of laminin and inhibitory CSPG. DRGn expressed the matrix metalloproteinase, MMP-2, which was transported to the growth cone. Recombinant MMP-2 inactivated the neurite-inhibiting CSPG without hindering the neurite-promoting potential of laminin. Similarly, neuritic growth by DRGn cultured on normal nerve sections was increased markedly by first treating the nerve sections with MMP-2. The proteolytic deinhibition by MMP-2 was equivalent to and nonadditive with that achieved by chondroitinase, suggesting that both enzymes inactivated inhibitory CSPG. Additionally, the increases in neuritic growth resulting from treating nerve sections with MMP-2 or chondroitinase were blocked by anti-laminin antibodies. From these results we conclude that MMP-2 provides a mechanism for the deinhibition of laminin in the endoneurial basal lamina and may play an important role in the regeneration of peripheral nerve.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Two members of this large group of ECM-degrading enzymes have been shown to have direct CSPG-degrading properties in the brain: MMP-2 and MMP-24 (Wang et al., 1999; Zuo et al., 1998)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Zuo et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268
The matrix‐degrading metalloproteinases
Matrisian, L. M. (1992) · BioEssays · doi:10.1002/bies.950140705 · Cited by 1,362
Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5
Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V. (1997) · Science · doi:10.1126/science.277.5323.225 · Cited by 1,221
Self-citationThe cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,203
Heumann, R., Korsching, S. I., Bandtlow, C. E., & Thoenen, H. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.6.1623 · Cited by 1,022
Laminin promotes neuritic regeneration from cultured peripheral and central neurons.
Manthorpe, M., Engvall, E., Ruoslahti, E. I., Longo, F. M., Davis, G. E., & Varon, S. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.6.1882 · Cited by 717
Schwann cell basal lamina and nerve regeneration
Idé, C., Tohyama, K., Yokota, R., Nitatori, T., & Onodera, S. (1983) · Brain Research · doi:10.1016/0006-8993(83)90081-1 · Cited by 508
Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina
Brittis, P. A., Canning, D. R., & Silver, J. (1992) · Science · doi:10.1126/science.1738848 · Cited by 415
Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth
Monard, D. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90182-8 · Cited by 336
Basbaum, C. B., & Werb, Z. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80116-5 · Cited by 324
Research works printed but not linked: 1
- Wyrwicka, 1950, On the rate of regeneration of the rat sciatic nerve in the white mouse., Acta Biol Exp (Warsz), 15, 147
Cited by
Sorted by citations
Nagase, H., & Woessner, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21491 · Cited by 3,905
The glial scar and central nervous system repair
Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,808
Metalloproteinases in biology and pathology of the nervous system
Yong, W. V., Power, C., Forsyth, P., & Edwards, D. (2001) · Nature Reviews Neuroscience · doi:10.1038/35081571 · Cited by 1,094
The Biology of Regeneration Failure and Success After Spinal Cord Injury
Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 903
Ramón‐Cueto, A., Cordero, M. I., Santos‐Benito, F. F., & Ávila, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80905-8 · Cited by 790
Metadata
- Authors
- Zuo, J., Ferguson, T. A., Hernandez, Y. J., Stetler-Stevenson, W. G., & Muir, D.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- ORCID
- Ferguson, Toby A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-07-15
- Volume
- 18
- Issue
- 14
- Pages
- 5203-5211
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6793496
- OpenAlex
- W1824808675
- Cited by
- 270
- References
- 54
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 10
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ns031255-05)
- National Institute of Neurological Disorders and Stroke (NS31255)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- MMP-2, chondroitin sulfate proteoglycans, neurite outgrowth inhibition, laminin, peripheral nerve regeneration, dorsal root ganglion neurons, chondroitinase, Schwann cells
- MeSH terms
- Animals, Biological Transport, Cells, Cultured, Chick Embryo, Chondroitinases and Chondroitin Lyases, Ganglia, Spinal, Laminin, Metalloendopeptidases, Nerve Regeneration, Neurons, Chondroitin Sulfate Proteoglycans, Recombinant Proteins, Cryopreservation, Neurites, Gelatinases, Matrix Metalloproteinase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
