Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat Hippocampus
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We examined the function of nicotinic acetylcholine receptors (nAChRs) in interneurons of area CA1 of the rat hippocampus. CA1 interneurons could be classified into three categories based on nicotinic responses. The first class was depolarized by α7 nAChRs, found in all layers of CA1 and as a group, had axonal projections to all neuropil layers of CA1. The second class had both fast α7 and slow non-α7 nAChR depolarizing responses, was localized primarily to the stratum oriens, and had axonal projections to the stratum lacunosum-moleculare. The third group had no nicotinic response. This group was found in or near the stratum pyramidale and had axonal projections almost exclusively within and around this layer. Low concentrations (500 n m) of nicotine desensitized fast and slow nAChR responses. These findings demonstrate that there are distinct subsets of interneurons with regard to nicotinic receptor expression and with predictable morphological properties that suggest potential cellular actions for nicotinic receptor activation in normal CNS function and during nicotine abuse.
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Increased inhibition through nAChR activation on interneurons occurs in many brain regions.
“Increased inhibition through activation of nAChRs expressed by interneurons has been found in many different brain regions (Jones and Yakel 1997; Xiang et al. 1998; McQuiston and Madison 1999; Alkondon et al. 2000; Ji and Dani 2000; Mansvelder et al. 2002; Gulledge et al. 2007).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as McQuiston and Madison 1999
The Figure 1 passage shows that nAChR activation excites interneurons in rat hippocampal CA1. In “Potential functional consequences of nonuniform nicotinic responsiveness in interneurons,” the authors propose that this could suppress input through inhibitory interneurons, but they do not report a measured increase in inhibition. This paper supplies a hippocampal example, not evidence across many brain regions by itself. (LLM, conf=0.84)
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References 53 · Cited by 239
Research works printed but not linked: 1
- Bolam JP (1992) E xperimental neuroanatomy: a practical approach. Ox- ford: Oxford UP.
- Authors
- McQuiston, A. R., & Madison, D. V.
- Affiliations
- Stanford Medicine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-04-15
- Volume
- 19
- Issue
- 8
- Pages
- 2887-2896
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6782295
- OpenAlex
- W1630155501
- Cited by
- 239
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 11 · 2014: 11 · 2013: 8 · 2012: 13
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh048874-02, 5r01mh056454-05)
- National Institute of Mental Health (MH 56454, MH-48874)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotinic acetylcholine receptors, hippocampal interneurons, CA1, alpha7 nicotinic acetylcholine receptor, interneuron subtypes, axonal projections, stratum oriens, stratum pyramidale, stratum lacunosum-moleculare, nicotine abuse
- MeSH terms
- Animals, Hippocampus, Interneurons, Membrane Potentials, Receptors, Nicotinic, Pyramidal Cells, Patch-Clamp Techniques, Rats
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