The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord.
Open accessAbstract
We have recently reported that minimally disturbed adult CNS white matter can support regeneration of adult axons by using a novel microtransplantation technique to inject minute volumes of dissociated adult rat dorsal root ganglion neurons directly into adult rat CNS pathways (Davies et al., 1997). This atraumatic injection procedure minimized scarring and allowed considerable numbers of regenerating adult axons immediate access to the adult CNS glial terrain where they rapidly extended for long distances. A critical question remained as to whether degenerating white matter at acute and chronic stages (up to 3 months) after injury could still support regeneration. To investigate this, we have microtransplanted adult sensory neurons into degenerating white matter of the adult rat spinal cord several millimeters rostral to a severe lesion of the dorsal columns. Regeneration of donor sensory axons in both directions away from the site of transplantation was robust even within white matter undergoing fulminant Wallerian degeneration despite intimate contact with myelin. Along their route, the regrowing axons extended large numbers of collaterals into the adjacent dorsal horn. However, after entering the lesion, the rapidly extending growth cones stopped and became dystrophic within high concentrations of reactive glial matrix. Our results offer compelling evidence that the major environmental impediment to regeneration in the adult CNS is the molecular barrier that forms directly at the lesion site, and that degenerating white matter beyond the glial scar has a far greater intrinsic ability to support axon regeneration than previously thought possible.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“which lead to denervation of upstream pathways and inactivation of parts of somatosensory cortex (Davies et al., 1999; Kaas et al., 2008).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Davies et al., 1999
In the citing paper
“When sensory axons were transplanted into adult rats with dorsal column lesions, neurons were able to sprout and extend their processes to additional denervated areas, but failed to penetrate the original lesion sites”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Davies et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Degeneration and Regeneration of the Nervous System.
(1929) · JAMA · doi:10.1001/jama.1929.02710220063037 · Cited by 2,908
‘Green mice’ as a source of ubiquitous green cells
Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T., & Nishimune, Y. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00313-x · Cited by 2,581
David, S., & Aguayo, A. J. (1981) · Science · doi:10.1126/science.6171034 · Cited by 1,698
McKeon, R., Schreiber, R., Rudge, J., & Silver, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03398.1991 · Cited by 1,188
Self-citationMcKerracher, L. J., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., & Braun, P. E. (1994) · Neuron · doi:10.1016/0896-6273(94)90247-x · Cited by 1,125
Microglia: Intrinsic immuneffector cell of the brain
Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111
Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury
Liu, X. Z., Xu, X. M., Hu, R., Du, C., Zhang, S. X., McDonald, J. W., Dong, H. X., Wu, Y. J., Fan, G. S., Jacquin, M. F., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05395.1997 · Cited by 770
Regeneration of adult axons in white matter tracts of the central nervous system
Davies, S. J. A., Fitch, M. T., Memberg, S. P., Hall, A. K., Raisman, G., & Silver, J. (1997) · Nature · doi:10.1038/37776 · Cited by 737
Self-citationSchwab, M. E., Kapfhammer, J. P., & Bandtlow, C. E. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.003025 · Cited by 539
Cai, D., Shen, Y.-J., de Bellard, M. E., Tang, S., & Filbin, M. T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80681-9 · Cited by 536
Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
Levine, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04716.1994 · Cited by 395
Snow, D. M., Steindler, D. A., & Silver, J. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90203-u · Cited by 387
Self-citationLaminin is induced in astrocytes of adult brain by injury.
Liesi, P., Kaakkola, S., Dahl, D. R., & Vaheri, A. I. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01867.x · Cited by 315
Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth
Smith, G. M., Rutishauser, U. S., Silver, J., & Miller, R. H. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90204-v · Cited by 298
Self-citationLaywell, E. D., Dörries, U., Bartsch, U., Faissner, A., Schachner, M., & Steindler, D. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2634 · Cited by 293
Hersch, S. M., Yi, H. L., Heilman, C. J., Edwards, R. H., & Levey, A. I. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19971117)388:2 · Cited by 290
Oligodendrocytes arrest neurite growth by contact inhibition
Bandtlow, C. E., Zachleder, T., & Schwab, M. E. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-12-03837.1990 · Cited by 283
Deposition of Scar Tissue in the Central Nervous System
Berry, M., Maxwell, W. L., Logan, A., Mathewson, A. J., Mcconnell, P., Ashhurst, D. E., & Thomas, G. H. (1983) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-4147-2_3 · Cited by 280
The Role of Macrophages in Wallerian Degeneration
Brück, W. (1997) · Brain Pathology · doi:10.1111/j.1750-3639.1997.tb01060.x · Cited by 280
Margolis, R. K., & Margolis, R. U. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923587 · Cited by 265
Neurite outgrowth on a step gradient of chondroitin sulfate proteoglycan (CS‐PG)
Snow, D. M., & Letourneau, P. C. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230311 · Cited by 217
The impact of microglia-derived cytokines upon gliosis in the CNS.
Giulian, D., Li, J., Li, X., George, J., & Rutecki, P. (1994) · Developmental Neuroscience · doi:10.1159/000112099 · Cited by 198
Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth
Condic, M. L., & Letourneau, P. C. (1997) · Nature · doi:10.1038/39878 · Cited by 192
Pasterkamp, R. J., de Winter, F., Holtmaat, A. J. D. G., & Verhaagen, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09962.1998 · Cited by 186
Goss, J. R., O’Malley, M. E., Zou, L., Styren, S. D., Kochanek, P. M., & DeKosky, S. T. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6712 · Cited by 164
Halloran, M., & Kalil, K. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02161.1994 · Cited by 153
Windle, W. F., Clemente, C., & Chambers, W. W. (1952) · The Journal of Comparative Neurology · doi:10.1002/cne.900960207 · Cited by 146
The fine structure of pulse labeled (3H‐thymidine cells) in degenerating rat optic nerve
Skoff, R. P. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901610408 · Cited by 129
Regeneration of Cut Adult Axons Fails Even in the Presence of Continuous Aligned Glial Pathways
Davies, S. J. A., Field, P. M., & Raisman, G. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0192 · Cited by 127
Self-citationMason, C. A., & Wang, L.-C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01086.1997 · Cited by 121
Maeda, N., & Noda, M. (1996) · Development · doi:10.1242/dev.122.2.647 · Cited by 120
Proteoglycans in the nervous system
Lander, A. D. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90143-m · Cited by 114
Canning, D. R., Höke, A., Malemud, C. J., & Silver, J. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00004-4 · Cited by 113
Self-citationSoluble Myelin-Associated Glycoprotein (MAG) Foundin VivoInhibits Axonal Regeneration
Tang, S., Woodhall, R. W., Shen, Y. J., de Bellard, M. E., Saffell, J. L., Doherty, P., Walsh, F. S., & Filbin, M. T. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0633 · Cited by 112
Koshinaga, M., & Whittemore, S. R. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.209 · Cited by 111
Höke, A., & Silver, J. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62538-8 · Cited by 93
Self-citationMansour, H., Asher, R., Dahl, D. R., Labkovsky, B., Perides, G., & Bignami, A. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490250306 · Cited by 91
Modification of astrocytes in the spinal cord following dorsal root or peripheral nerve lesions
Murray, M., Wang, S., Goldberger, M. E., & Levitt, P. R. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90036-r · Cited by 91
Long interfascicular axon growth from embryonic neurons transplanted into adult myelinated tracts
Davies, S., Field, P., & Raisman, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01596.1994 · Cited by 90
Self-citationThe proximo-distal spread of axonal degeneration in the dorsal columns of the rat
George, R., & Griffin, J. W. (1994) · Journal of Neurocytology · doi:10.1007/bf01181641 · Cited by 83
Golovina, V. A., Bambrick, L. L., Yarowsky, P., Krueger, B. K., & Blaustein, M. P. (1996) · Glia · doi:10.1002/(sici)1098-1136(199604)16:4 · Cited by 80
Davies, S. J. A., Field, P. M., & Raisman, G. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00474.x · Cited by 76
Self-citationOrigin of the connective tissue scar in the transected rat spinal cord
Krikorian, J. G., Guth, L., & Donati, E. J. (1981) · Experimental Neurology · doi:10.1016/0014-4886(81)90018-2 · Cited by 71
DiProspero, N. A., Meiners, S. A., & Geller, H. M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6700 · Cited by 68
p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway
Wr, M., Whitesides, J. G., LaMantia, A., & Maness, P. F. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199807)36:1 · Cited by 54
Franson, P., & Ronnevi, L. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230111 · Cited by 52
Heterogeneity among astrocytes in reactive gliosis.
Höke, A., & Silver, J. (1994) · PubMed · Cited by 52
Self-citationArd, M. D., Bunge, M. B., Wood, P. M., Schachner, M., & Bunge, R. P. (1991) · Glia · doi:10.1002/glia.440040109 · Cited by 42
Microtransplantation of neural cells into adult rat brain
Emmett, C. J., Jaques-Berg, W., & Seeley, P. J. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90387-j · Cited by 37
Roux, P. D. L., & Reh, T. A. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0006 · Cited by 36
Palladini, G., Caronti, B., Pozzessere, G., Teichner, A., Buttarelli, F. R., Morselli, E., Valle, E., Venturini, G., Fortuna, A., & Pontieri, F. E. (1996) · PubMed · Cited by 28
Axonal growth on astrocytes is not inhibited by oligodendrocytes
Fawcett, J. W., Fersht, N. L., Housden, L., Schachner, M., & Pesheva, P. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.2.571 · Cited by 23
Does CNS Myelin Inhibit Axon Regeneration?
Fields, R. D., Schwab, M. E., & Silver, J. (1999) · The Neuroscientist · doi:10.1177/107385849900500103 · Cited by 6
Self-citation
Research works printed but not linked: 2
- Huber, 1998, Developmental expression pattern and functional analysis of NOGO (formerly NI-35/250), a major inhibitor of CNS regeneration., Soc Neurosci Abstr, 24, 616.6
- McKeon, 1997, Gene expression in glial scars following CNS injury., Soc Neurosci Abstr, 23, 777.1
Cited by
Sorted by citations
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Self-citationChondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury
Faulkner, J. R., Herrmann, J. E., Woo, M. J., Tansey, K. E., Doan, N., & Sofroniew, M. V. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3547-03.2004 · Cited by 1,652
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
Self-citation
Metadata
- Authors
- Davies, S. J. A., Goucher, D. R., Doller, C., & Silver, J.
- Affiliations
- Case Western Reserve University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-07-15
- Volume
- 19
- Issue
- 14
- Pages
- 5810-5822
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6783087
- OpenAlex
- W1826719783
- Cited by
- 606
- References
- 54
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 27 · 2013: 22 · 2012: 39
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 25713)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- axon regeneration, spinal cord injury, dorsal root ganglion neurons, microtransplantation, Wallerian degeneration, glial scar, sensory axons, dorsal horn, myelin, dorsal column lesion
- MeSH terms
- Animals, Astrocytes, Axons, Cells, Cultured, Chickens, Ganglia, Spinal, Luminescent Proteins, Mice, Inbred C57BL, Mice, Transgenic, Myelin Sheath, Nerve Degeneration, Nerve Regeneration, Neurons, Neurons, Afferent, Oligodendroglia, Spinal Cord, Time Factors, Rats, Sprague-Dawley, Coculture Techniques, Green Fluorescent Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
