The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Dependence of Nodal Sodium Channel Clustering on Paranodal Axoglial Contact in the Developing CNS
Open accessAbstract
Na(+) channel clustering at nodes of Ranvier in the developing rat optic nerve was analyzed to determine mechanisms of localization, including the possible requirement for glial contact in vivo. Immunofluorescence labeling for myelin-associated glycoprotein and for the protein Caspr, a component of axoglial junctions, indicated that oligodendrocytes were present, and paranodal structures formed, as early as postnatal day 7 (P7). However, the first Na(+) channel clusters were not seen until P9. Most of these were broad, and all were excluded from paranodal regions of axoglial contact. The number of detected Na(+) channel clusters increased rapidly from P12 to P22. During this same period, conduction velocity increased sharply, and Na(+) channel clusters became much more focal. To test further whether oligodendrocyte contact directly influences Na(+) channel distributions, nodes of Ranvier in the hypomyelinating mouse Shiverer were examined. This mutant has oligodendrocyte-ensheathed axons but lacks compact myelin and normal axoglial junctions. During development Na(+) channel clusters in Shiverer mice were reduced in numbers and were in aberrant locations. The subcellular location of Caspr was disrupted, and nerve conduction properties remained immature. These results indicate that in vivo, Na(+) channel clustering at nodes depends not only on the presence of oligodendrocytes but also on specific axoglial contact at paranodal junctions. In rats, ankyrin-3/G, a cytoskeletal protein implicated in Na(+) channel clustering, was detected before Na(+) channel immunoreactivity but extended into paranodes in non-nodal distributions. In Shiverer, ankyrin-3/G labeling was abnormal, suggesting that its localization also depends on axoglial contact.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Deficits in myelination and oligodendrocyte maturation can also lead to impaired formation of the nodes of Ranvier (Kaplan et al., 2001; Rasband et al., 1999; Tanaka et al., 2009).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Rasband et al., 1999
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons
Wang, H., Kunkel, D. D., Martin, T. M., Schwartzkroin, P. A., & Tempel, B. L. (1993) · Nature · doi:10.1038/365075a0 · Cited by 647
Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1295 · Cited by 568
Primary structure and functional expression of a mammalian skeletal muscle sodium channel
Trimmer, J. S., Cooperman, S. S., Tomiko, S. A., Zhou, J., Crean, S. M., Boyle, M. B., Kallen, R. G., SHENG, Z.-H., Barchi, R. L., Sigworth, F. J., et al. (1989) · Neuron · doi:10.1016/0896-6273(89)90113-x · Cited by 562
Self-citationKordeli, E., Lambert, S., & Bennett, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2352 · Cited by 489
Martini, R., & Schachner, M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2439 · Cited by 488
Ankyrin and spectrin associate with voltage-dependent sodium channels in brain
Srinivasan, Y., Elmer, L. W., Davis, J. Q., Bennett, V., & Angelides, K. J. (1988) · Nature · doi:10.1038/333177a0 · Cited by 416
Peles, E., Nativ, M., Lustig, M., Grumet, M., Schilling, J., Martinez, R., Plowman, G. D., & Schlessinger, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.978 · Cited by 400 · cited 2×
“The polyclonal anti-Caspr was generated against a bacterial fusion protein containing the cytoplasmic domain and was used at a dilution of 1:2500 (Peles et al., 1997).”
MethodSelf-citationEinheber, S., Zanazzi, G., Ching, W., Scherer, S., Milner, T. A., Peles, E., & Salzer, J. L. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.6.1495 · Cited by 369
Self-citationSkoff, R. P., Price, D. L., & Stocks, A. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690303 · Cited by 362
Davis, J. Q., Lambert, S., & Bennett, V. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.5.1355 · Cited by 347
Cited by
Sorted by citations
Items 301–325 of 325
Multiple roles for integrins in Drosophila glial development
Xie, X. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072946
Cellular Elements, Tissue Organization, Organogenesis
Dupree, J. L. (2002) · Elsevier eBooks · doi:10.1016/b978-044451002-0/50002-6
Exercise-induced Hypoalgesia Profiles for Pain Prediction in the Trigeminal System
Assiri, K. I. (2016) · World Journal of Dentistry · doi:10.5005/jp-journals-10015-1405
Nav1.2 Voltage-Gated Sodium Channel
Scholz, A. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60408-8
Functions of Fibroblast Growth Factor Homologous Factor 2 in Excitable Tissues
Marra, C. (2020) · CUNY Academic Works (City University of New York)
Investigation of myelin maintenance and turnover by inducible MBP knock-out in adult mice
Meschkat, M. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7679
Role of Ectosomes in the Design of the Myelinated Axon: Structural FindPreprint
Szuchet, S., O’Sullivan, S. A., Arvans, D. L., & Domowicz, M. S. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3525551
(2001) · Elsevier eBooks · doi:10.1016/b978-0-12-311624-6.50006-2
Rasband, M. N., & Shrager, P. G. (2013) · Springer eBooks · doi:10.1007/978-3-642-28753-4_1026
Self-citation(2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.50022-7
Rasband, M. N., & Shrager, P. G. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_1026
Self-citationStructure and function of myelinated axons
Buffington, S. A., & Rasband, M. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00040-0
Self-citationMcKee, C., Foley, K., Andersh, K. M., Marola, O. J., Wadzinski, B. E., Libby, R. T., Shrager, P. G., & Xia, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.10.593531
Self-citationMechanisms of central nervous system nodes of Ranvier assembly
Freeman, S. A. (2015) · theses.fr (ABES) · doi:10.70675/8a8a095cze5faz4cd3z8fcez185fe0291fb2
Thétiot, M. (2018) · theses.fr (ABES) · doi:10.70675/4fd006d4z6c0ez4fe8zbcd0z0df8b8ef8d85
Microglia-nodes of Ranvier interaction during repair
Roux, T. (2020) · theses.fr (ABES) · doi:10.70675/a1319259z2b39z4d4ez9c05z261e4533646b
Masson, M. L. P. (2024) · theses.fr (ABES) · doi:10.70675/7f680c8dz2453z40c7z9047z982a66a8bfd5
Hasegawa, K., Hama, N., Amemiya, M., Zeng, C., Ito, Y., Suzuki, S., Nakamura, K., Kondo, J., Takeda, C., Kurihara, Y., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00786-5
Ievglevskyi, O., Zosen, D., Osete, J. R., Glover, J. C., Paulsen, R. E., Djurovic, S., & Kondratskaya, E. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00823
The Role Of The Periaxonal Space In Sustained Impulse Conduction
Trigo, D. (2014) · UCL Discovery (University College London) · Cited by 1
Sodium channel expression and function in multiple sclerosis
Bangalore, L., Black, J. A., Carrithers, M. D., & Waxman, S. G. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781698.005
Goodrum (2000) · doi:10.1002/(sici)1097-4547(20000215)59:4
Metadata
- Authors
- Rasband, M. N., Peles, E., Trimmer, J. S., Levinson, S. R., Lux, S. E., & Shrager, P.
- Affiliations
- Weizmann Institute of Science (IL)
- Stony Brook University (US)
- University of Colorado Denver (US)
- Boston Children's Hospital (US)
- University of Rochester Medicine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-09-01
- Volume
- 19
- Issue
- 17
- Pages
- 7516-7528
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6782503
- OpenAlex
- W1788586683
- Cited by
- 325
- References
- 58
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 18 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 17 · 2015: 9 · 2014: 11 · 2013: 14 · 2012: 8
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society
- National Institutes of Health (5p01ns034375-05, NS34375)
- National Heart, Lung, and Blood Institute (P01HL032262)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK034083)
- National Institute of Neurological Disorders and Stroke (NS-34375, R01NS017965, NS34383, NS 17965, R01NS034383, R37NS034383)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- nodes of Ranvier, paranodal junctions, oligodendrocytes, optic nerve development, myelination, myelin-associated glycoprotein, Caspr, shiverer mice, hypomyelination, nerve conduction velocity
- MeSH terms
- Action Potentials, Aging, Amino Acid Sequence, Animals, Epitopes, Axons, Cell Communication, Mice, Inbred C3H, Mice, Neurologic Mutants, Molecular Sequence Data, Myelin Sheath, Neural Conduction, Neuroglia, Oligodendroglia, Optic Nerve, Ranvier's Nodes, Receptors, Cell Surface, Sodium Channels, Cell Adhesion Molecules, Neuronal, Gene Expression Regulation, Developmental, Mice, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
