Cited by 113Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

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The Two Isoforms of the Caenorhabditis elegans Leukocyte-Common Antigen Related Receptor Tyrosine Phosphatase PTP-3 Function Independently in Axon Guidance and Synapse Formation

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Ackley, Brian D., Harrington, Robert J., Hudson, Martin L., Williams, Lisa, Kenyon, Cynthia J., Chisholm, Andrew D., Jin, Yishi·2005·The Journal of Neuroscience

DOI 10.1523/jneurosci.2010-05.2005PMC PMC6725402

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Abstract

Leukocyte-common antigen related (LAR)-like phosphatase receptors are conserved cell adhesion molecules that function in multiple developmental processes. The Caenorhabditis elegans ptp-3 gene encodes two LAR family isoforms that differ in the extracellular domain. We show here that the long isoform, PTP-3A, localizes specifically at synapses and that the short isoform, PTP-3B, is extrasynaptic. Mutations in ptp-3 cause defects in axon guidance that can be rescued by PTP-3B but not by PTP-3A. Mutations that specifically affect ptp-3A do not affect axon guidance but instead cause alterations in synapse morphology. Genetic double-mutant analysis is consistent with ptp-3A acting with the extracellular matrix component nidogen,nid-1, and the intracellular adaptor α-liprin,syd-2.nid-1 and syd-2 are required for the recruitment and stability of PTP-3A at synapses, and mutations in ptp-3 or nid-1 result in aberrant localization of SYD-2. Overexpression of PTP-3A is able to bypass the requirement for nid-1 for the localization of SYD-2 and RIM. We propose that PTP-3A acts as a molecular link between the extracellular matrix and α-liprin during synaptogenesis.

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Authors: Ackley, B. D., Harrington, R. J., Hudson, M. L., Williams, L., Kenyon, C. J., Chisholm, A. D., & Jin, Y.
Affiliations: University of California, Santa Cruz (US)
University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
Corresponding author: Jin, Yishi
ORCID: Ackley, Brian D.
Hudson, Martin L.
Kenyon, Cynthia J.
Chisholm, Andrew D.
Jin, Yishi
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-08-17
Volume: 25
Issue: 33
Pages: 7517-7528
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.2010-05.2005
PMC: PMC6725402
OpenAlex: W1984882339
Cited by: 113
References: 48
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 3 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 4
FWCI: 2.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute (NS35546)
Muscular Dystrophy Association
National Institutes of Health (GM54657)
National Institute of General Medical Sciences (GM54657, R01GM054657)
National Institute of Neurological Disorders and Stroke (R37NS035546, R01NS035546, NS35546)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Caenorhabditis elegans, isoform-specific function, axon guidance, synaptogenesis, synaptic morphology, nidogen, RIM, extracellular matrix, synaptic localization, adhesion molecules
MeSH terms: Animals, Axons, Mutation, Nerve Tissue Proteins, Receptors, Cell Surface, Synapses, Protein Tyrosine Phosphatases, Caenorhabditis elegans, Protein Isoforms, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Intracellular Signaling Peptides and Proteins, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Receptor-Like Protein Tyrosine Phosphatases, Class 2

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The Two Isoforms of the Caenorhabditis elegans Leukocyte-Common Antigen Related Receptor Tyrosine Phosphatase PTP-3 Function Independently in Axon Guidance and Synapse Formation

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