The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Role of Dopamine in the Nucleus Accumbens and Striatum during Sexual Behavior in the Female Rat
Open accessAbstract
Dopamine in dialysate from the nucleus accumbens (NAcc) increases during sexual and feeding behavior and after administration of drugs of abuse, even those that do not directly activate dopaminergic systems (e.g., morphine or nicotine). These findings and others have led to hypotheses that propose that dopamine is rewarding, predicts that reinforcement will occur, or attributes incentive salience. Examining increases in dopamine in NAcc or striatum during sexual behavior in female rats provides a unique situation to study these relations. This is because, for the female rat, sexual behavior is associated with an increase in NAcc dopamine and conditioned place preference only under certain testing conditions. This experiment was conducted to determine what factors are important for the increase in dopamine in dialysate from NAcc and striatum during sexual behavior in female rats. The factors considered were the number of contacts by the male, the timing of contacts by the male, or the ability of the female to control contacts by the male. The results indicate that increased NAcc dopamine is dependent on the timing of copulatory stimuli, independent of whether the female rat is actively engaged in regulating this timing. For the striatum, the timing of copulatory behavior influences the magnitude of the increase in dopamine in dialysate, but other factors are also involved. We conclude that increased extracellular dopamine in the NAcc and striatum conveys qualitative or interpretive information about the rewarding value of stimuli. Sexual behavior in the female rat is proposed as a model to determine the role of dopamine in motivated behavior.
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“Dopaminergic release within the nucleus accumbens only appears to occur when females copulate according to their pacing preferences (Becker et al., 2001, Jenkins and Becker, 2003a, Mermelstein and Becker, 1995).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Becker et al., 2001
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Cites
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Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats
Pfaus, J. G., Damsma, G., Wenkstern, D., & Fibiger, H. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00679-k · Cited by 236
Sexual behavior regulated (paced) by the female induces conditioned place preference.
Paredes, R. G., & Alonso, A. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.1.123 · Cited by 215
Becker, J. B., & Rudick, C. N. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00091-x · Cited by 194
Mermelstein, P. G., & Becker, J. B. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.2.354 · Cited by 186
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Spreckelmeyer, K. N. (2011) · Springer eBooks · doi:10.1007/978-3-642-25476-5_30
Pitchers, K. K. (2012) · Scholarship@Western (Western University)
Sex and estrous phase influence functional connectivity during fear extinction
Hohorst, A. A., Westerman, J. D., Sanchez-Mendoza, C., Tanner, M. K., Dryden, M. Q., Freund, J. R., Abdul, R. A., Crombie, K. M., & Greenwood, B. N. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116039
Zhai, J., Xu, Z., Yu, X., Shi, K., Zhang, X., Kuniishi, H., Xie, M. J., Zhang, Y., Yao, X., Wang, X., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70690
Estradiol Sensitization of Sexual Behaviors in the Ovariectomized Rat: Mechanisms and Applications
Jones, S. L. (2015) · Spectrum Research Repository (Concordia University)
Metadata
- Authors
- Becker, J. B., Rudick, C. N., & Jenkins, W. J.
- Affiliations
- University of Michigan (US)
- ORCID
- Becker, Jill B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-05-01
- Volume
- 21
- Issue
- 9
- Pages
- 3236-3241
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762549
- OpenAlex
- W1721700897
- Cited by
- 206
- References
- 21
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 1 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 13
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9816673)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, nucleus accumbens, striatum, female sexual behavior, mating behavior, extracellular dopamine, reward, incentive salience, conditioned place preference, motivated behavior, female rats
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Corpus Striatum, Dopamine, Estradiol, Extracellular Space, Female, Homovanillic Acid, Male, Motivation, Nucleus Accumbens, Ovariectomy, Periodicity, Progesterone, Reaction Time, Sexual Behavior, Animal, 3,4-Dihydroxyphenylacetic Acid, Microdialysis, Rats, Long-Evans, Rats
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