The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Proteinase-Activated Receptor 2 Is Involved in Nociception
Open accessAbstract
The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We hypothesized that this receptor may also play a role in neuronal sensitization and contribute to the pathogenesis of pain in inflammatory conditions such as pancreatitis. Using a specific proteinase-activated receptor 2 activating peptide, we found evidence of such sensitization in vitro in the form of enhanced capsaicin- and KCl-evoked release of calcitonin gene-related peptide, a marker for nociceptive signaling. We then demonstrated that injection of the proteinase-activated receptor 2 activating peptide into the pancreatic duct can activate and sensitize pancreas-specific afferent neurons in vivo, as measured by Fos expression in the dorsal horn of the spinal cord. These observations suggest that proteinase-activated receptor 2 contributes to nociceptive signaling and may provide a novel link between inflammation and pain.
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Cites
Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
Kawabata, A., Kawao, N., Kuroda, R., Tanaka, A., Itoh, H., & Nishikawa, H. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00020 · Cited by 94
Cited by
Protease-Activated Receptors: Contribution to Physiology and Disease
OSSOVSKAYA, V. S., & BUNNETT, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,078
The role of mast cells in the pathogenesis of pain in chronic pancreatitis
Hoogerwerf, W. A., Gondesen, K., Xiao, S.-Y., Winston, J. H., Willis, W. D., & Pasricha, P. J. (2005) · BMC Gastroenterology · doi:10.1186/1471-230x-5-8 · Cited by 61
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Metadata
- Authors
- Hoogerwerf, W. A., Zou, L., Shenoy, M., Sun, D., Micci, M. A., Lee-Hellmich, H., Xiao, S. Y., Winston, J. H., & Pasricha, P. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-11-15
- Volume
- 21
- Issue
- 22
- Pages
- 9036-9042
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2120415921
- Cited by
- 171
- References
- 1
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hoogerwerf, W. A., Zou, L., Shenoy, M., Sun, D., Micci, M. A., Lee-Hellmich, H., Xiao, S. Y., Winston, J. H., & Pasricha, P. J. (2001). The Proteinase-Activated Receptor 2 Is Involved in Nociception. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-22-09036.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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