The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hydrogen Sulfide Is Produced in Response to Neuronal Excitation
Open accessAbstract
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. This increased CBS activity is regulated by a pathway involving Ca2+/calmodulin. In addition, LTP is altered in CBS knock-out mice. These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.
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Citations
Cites
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285
Cited by
H2S generated by heart in rat and its effects on cardiac function
Geng, B., Yang, J., Qi, Y., Zhao, J., Pang, Y., Du, J., & Tang, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.130 · Cited by 342
Metadata
- Authors
- Eto, K., Ogasawara, M., Umemura, K., Nagai, Y., & Kimura, H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-05-01
- Volume
- 22
- Issue
- 9
- Pages
- 3386-3391
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1789963253
- Cited by
- 172
- References
- 1
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- Eto, K., Ogasawara, M., Umemura, K., Nagai, Y., & Kimura, H. (2002). Hydrogen Sulfide Is Produced in Response to Neuronal Excitation. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-09-03386.2002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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