The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Connexin Mediates Gap Junction-Independent Resistance to Cellular Injury
Open accessAbstract
Although gap junctions regulate essential processes during development and differentiation, the role of gap junctions in cell death is poorly understood. We demonstrate here that the forced expression of connexin 43 (Cx43), the main constituent of astrocytic gap junctions, protected against cell injury with a potency that was comparable with that from the expression of the proto-oncogene bcl2. The expression of two other members of the Cx family, Cx32 and Cx40, also increased the resistance to injury from exposures to calcium overload, oxidative stress, metabolic inhibition, tamoxifen, and UV irradiation, but not against staurosporine- and dexamethasone-mediated death. Surprisingly, the anti-death activity of connexin proteins was independent of gap junction channel function, because physical isolation or the pharmacological inhibition of coupling did not significantly increase cell death. Moreover, cells expressing nonfunctional mutant connexins also acquired a high resistance to injury. These observations identify Cx proteins as active players in cell survival.
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Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Milian, J. A., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90410-7 · Cited by 857
Cotrina, M. L., Lin, J. H.-C., López-Garcı́a, J. C., Naus, C. C. G., & Nedergaard, M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02835.2000 · Cited by 388
Self-citationBillecke, C. A., Ljungman, M. E., McKay, B. C., Rehemtulla, A., Taneja, N., & Ethier, S. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205546 · Cited by 28
Cited by
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Wang, X., Arcuino, G., Takano, T., Lin, J., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 494
Self-citationAstrocytic contributions to bioenergetics of cerebral ischemia
Dienel, G. A., & Hertz, L. (2005) · Glia · doi:10.1002/glia.20157 · Cited by 150
Metadata
- Authors
- Lin, J. H.-C., Yang, J., Liu, S., Takano, T., Wang, X., Gao, Q., Willecke, K., & Nedergaard, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-01-15
- Volume
- 23
- Issue
- 2
- Pages
- 430-441
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2157753339
- Cited by
- 173
- References
- 4
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lin, J. H.-C., Yang, J., Liu, S., Takano, T., Wang, X., Gao, Q., Willecke, K., & Nedergaard, M. (2003). Connexin Mediates Gap Junction-Independent Resistance to Cellular Injury. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-02-00430.2003
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