The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Vesicular Neurotransmitter Transporter Expression in Developing Postnatal Rodent Retina: GABA and Glycine Precede Glutamate
Open accessAbstract
Vesicular transporters regulate the amount and type of neurotransmitter sequestered into synaptic vesicles and, hence, the kind of signal transmitted to postsynaptic neurons. Glutamate is the prominent excitatory neurotransmitter in retina; GABA and glycine are the main inhibitory neurotransmitters. Little is known about the ontogeny of vesicular neurotransmission in retina. We investigated expression of glutamatergic [vesicular glutamate transporter 1 (VGLUT1)] and GABA/glycinergic [vesicular GABA/glycine transporter (VGAT)] vesicular transporters in postnatal retina. VGLUT1 labels glutamatergic synapses. VGLUT1 and synaptic vesicle 2 colocalized to photoreceptor terminals. VGLUT1 colocalized with PKC to rod bipolar terminals and to ON bipolar terminals in metabotropic glutamate receptor 6+/- mice. Developmentally, VGAT expression precedes VGLUT1. In rat and mouse retina, VGAT occurred in the inner retina by postnatal day 1 (P1). In rat retina, VGLUT1 was in the outer retina by P5-P7 and the inner retina by P7. In the mouse retina, VGLUT1 expression was in the outer retina by P3 and the inner retina by P5. Both rat and mouse retina had an adult pattern of VGLUT1 expression by P14. VGLUT1 expression precedes ribbon synapses, which are first observed in the inner retina at P11 (Fisher, 1979) in mouse and P13 (Horsburgh and Sefton, 1987) in rat. The ribbon synapse marker RIBEYE was not detected in inner retina of P5 or P7 rat. Spontaneous EPSCs in mouse ganglion cells were recorded as early as P7. Together, these findings indicate that vesicular GABA and glycine transmission precedes vesicular glutamate transmission in developing rodent retina. Furthermore, vesicular glutamate transmission likely occurs before ribbon synapse formation in the inner retina.
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“We examined changes in endogenous vesicular glutamate transporter 1 (VGLUT-1), a presynaptic protein expressed at bipolar ribbon synapses [37], and postsynaptic density protein 95 (PSD95) in the inner plexiform layer, where RGC dendrites are located.”
From AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma (2021) · cites this paper as [37]
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Cites
The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, R. T., Troyer, M. D., Pahner, I., Nygaard, G. O., Tran, C. H., Reimer, R. J., Bellocchio, E. E., Fortin, D. L., Storm‐Mathisen, J., & Edwards, R. H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00344-0 · Cited by 1,266
Self-citationIdentification and characterization of the vesicular GABA transporter
McIntire, S. L., Reimer, R. J., Schuske, K., Edwards, R. H., & Jørgensen, E. M. (1997) · Nature · doi:10.1038/39908 · Cited by 886
Self-citationTakamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795
Self-citationBuckley, K. M., & Kelly, R. B. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.4.1284 · Cited by 713
Chaudhry, F. A., Reimer, R. J., Bellocchio, E. E., Danbolt, N. C., Osen, K. K., Edwards, R. H., & Storm‐Mathisen, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09733.1998 · Cited by 640
Self-citationRIBEYE, a Component of Synaptic Ribbons
Schmitz, F., Königstorfer, A., & Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00159-8 · Cited by 581
Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals
von Gersdorff, H., & Mathews, G. (1994) · Nature · doi:10.1038/367735a0 · Cited by 457
Rod bipolar cells in the mammalian retina show protein kinase C‐like immunoreactivity
Greferath, U., Grünert, U., & Wässle, H. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903010308 · Cited by 420
Lee, R., Sawin, E. R., Chalfie, M., Horvitz, H. R., & Avery, L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00159.1999 · Cited by 351
Cited by
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Functional architecture of the retina: Development and disease
Hoon, M., Okawa, H., Santina, L. D., & Wong, R. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.003 · Cited by 628
Sensorineural Deafness and Seizures in Mice Lacking Vesicular Glutamate Transporter 3
Seal, R. P., Akil, O., Yi, E., Weber, C. M., Grant, L. M., Yoo, J. W., Clause, A. R., Kandler, K., Noebels, J. L., Glowatzki, E., et al. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.032 · Cited by 414
Self-citationTypes of bipolar cells in the mouse retina
Ghosh, K. K., Bujan, S., Haverkamp, S., Feigenspan, A., & Wässle, H. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10985 · Cited by 378
Visual Stimulation Is Required for Refinement of ON and OFF Pathways in Postnatal Retina
Tian, N., & Copenhagen, D. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00389-1 · Cited by 304
Self-citationLateral interactions in the outer retina
Thoreson, W. B., & Mangel, S. C. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.04.003 · Cited by 253
Metadata
- Authors
- Johnson, J., Tian, N., Caywood, M. S., Reimer, R. J., Edwards, R. H., & Copenhagen, D. R.
- Affiliations
- Yale University (US)
- Stanford Medicine (US)
- University of California, San Francisco (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-01-15
- Volume
- 23
- Issue
- 2
- Pages
- 518-529
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741860
- OpenAlex
- W1545065700
- Cited by
- 197
- References
- 42
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 17 · 2012: 13
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research to Prevent Blindness
- That Man May See
- National Institutes of Health
- National Eye Institute (R01EY001869)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- VGLUT1, vesicular GABA transporter, glutamatergic synapses, GABAergic synapses, photoreceptor terminals, rod bipolar cells, ON bipolar cells, mGluR6, protein kinase C, ribeye, spontaneous EPSCs, retinal ganglion cells
- MeSH terms
- Age Factors, Animals, Carrier Proteins, gamma-Aminobutyric Acid, Glycine, Heterozygote, Membrane Glycoproteins, Membrane Proteins, Mice, Inbred C57BL, Mice, Mutant Strains, Nerve Tissue Proteins, Neurons, Retina, Retinal Ganglion Cells, Presynaptic Terminals, Patch-Clamp Techniques, Glutamic Acid, Excitatory Postsynaptic Potentials, Rats, Long-Evans, Photoreceptor Cells, Vertebrate, Membrane Transport Proteins, Organic Anion Transporters, Vesicular Transport Proteins, GABA Plasma Membrane Transport Proteins, Vesicular Glutamate Transport Protein 1, Mice, Rats, In Vitro Techniques
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