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Cited by 210Ion channel regulation and functionDeep Brain Stimulation and Movement DisordersCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.

Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro

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Hallworth, Nicholas E., Wilson, Charles J., Bevan, Mark D.·2003·The Journal of Neuroscience
DOI 10.1523/jneurosci.23-20-07525.2003PMC PMC6740770
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Abstract

Distinct activity patterns in subthalamic nucleus (STN) neurons are observed during normal voluntary movement and abnormal movement in Parkinson's disease (PD). To determine how such patterns of activity are regulated by small conductance (SK) calcium-activated potassium channels (K Ca ) and voltage-gated calcium (Ca v ) channels, STN neurons were recorded in the perforated patch configuration in slices, [which were prepared from postnatal day 16 (P16)-P30 rats and held at 37°C] and then treated with the SK K Ca channel antagonist apamin or the SK K Ca agonist 1-ethyl-2-benzimidazolinone or the Ca v channel antagonists ω-conotoxin GVIA (Ca v 2.2-selective) or nifedipine (Ca v 1.2-1.3-selective). In other experiments, fura-2 was introduced as an indicator of intracellular calcium dynamics. A component of the current underlying single-spike afterhyperpolarization was sensitive to apamin, phase-locked to calcium entry via Ca v 2.2 channels, and necessary for precise, autonomous, single-spike oscillation. SK K Ca /Ca v 2.2 channel coupling did not underlie spike-frequency adaptation but limited activity in response to current injection by encoding the accumulation of intracellular calcium, maintained the characteristic sigmoidal frequency-intensity relationship and generated a post-train afterhyperpolarization. In addition, SK K Ca channels terminated rebound burst activity more effectively in neurons with short-duration bursts (<100 msec) than neurons with long-duration bursts (>100 msec), presumably through their activation by Ca v 3 channels. Ca v 1.2-1.3 channels were not strongly coupled to SK K Ca channels and therefore supported secondary range and long-duration rebound burst firing. In summary, SK K Ca channels play a fundamental role in autonomous, driven, and rebound activity and oppose the transition from autonomous, rhythmic, single-spike activity to burst firing in STN neurons.

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Research works printed but not linked: 4

  1. 2002, Soc Neurosci Abstr, 22, 217.6
  2. 2001, Adv Neurol, 86, 405
  3. 2002, Mov Disord, 17, S63
  4. 1996, J Neurosci Methods, 68, 221

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Metadata

Authors
Hallworth, N. E., Wilson, C. J., & Bevan, M. D.
Affiliations
Northwestern University (US)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2003-08-20
Volume
23
Issue
20
Pages
7525-7542
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.23-20-07525.2003
PMC
PMC6740770
OpenAlex
W1823433896
Cited by
210
References
91
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 13 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 15
FWCI
4.83
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS-41280, R01NS020702, NS-20702, NS26473, R37NS041280, NS047085, P50NS047085, R01NS041280)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
small conductance calcium-activated potassium channels, apamin, voltage-gated calcium channels, N-type calcium channels, Cav3 channels, channel coupling, action potential generation, afterhyperpolarization, intracellular calcium dynamics, Parkinson's disease, neuronal firing patterns
MeSH terms
Action Potentials, Animals, Apamin, Calcium, Calcium Channel Blockers, Cells, Cultured, Kinetics, Neurons, Periodicity, Calcium Channels, Potassium Channels, Ion Transport, Rats, Sprague-Dawley, Patch-Clamp Techniques, Subthalamic Nucleus, Calcium Channels, L-Type, Potassium Channels, Calcium-Activated, Potassium Channel Blockers, Rats, Small-Conductance Calcium-Activated Potassium Channels

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