In Vivo Magnetic Resonance Microimaging of Individual Amyloid Plaques in Alzheimer's Transgenic Mice
Open accessAbstract
The ability to detect individual Alzheimer's amyloid plaques in vivo by magnetic resonance microimaging (MRI) should improve diagnosis and also accelerate discovery of effective therapeutic agents for Alzheimer's disease (AD). Here, we perform in vivo and ex vivo MRI on double transgenic AD mice as well as wild-type mice at varying ages and correlate these with thioflavin-S and iron staining histology. Quantitative counts of individual plaques on MRI increase with age and correlate with histologically determined plaque burden. Plaques 20 microm in diameter can be detected in AD mice as young as 3 months of age with ex vivo MRI. Plaques 35 microm in diameter can be detected by 9 months of age with in vivo MRI. In vivo MRI of individual Alzheimer's amyloid plaques provides a noninvasive estimate of plaque burden in transgenic AD mice that might be useful in assessing the efficacy of amyloid reduction therapies.
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Aβ plaques could also be detected in mouse AD models using a high-resolution T2-weighted spin-echo sequence.
“The Aβ plaques could also be detected in mouse AD models using a high-resolution T2-weighted spin-echo sequence (Jack et al., 2005).”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Jack et al., 2005
MRI scans of post-mortem human brains and a mouse model of Alzheimer's disease show decreases in hippocampal T2* MRI, which is sensitive to the magnetic properties of iron or its spatial variance, attributed in part to iron in Aβ plaques.
“MRI scans of post-mortem human brains and a mouse model of Alzheimer’s disease show decreases in hippocampal T2* MRI, which is sensitive to the magnetic properties of iron86,87 or its spatial variance, attributed in part to iron in Aβ plaques.88–90”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [88]
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References 28 · Cited by 148
- Authors
- Jack, C. R., Wengenack, T. M., Reyes, D. A., Garwood, M., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Adriany, G., & Poduslo, J. F.
- Affiliations
- Mayo Clinic (US)
- University of Minnesota (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-26
- Volume
- 25
- Issue
- 43
- Pages
- 10041-10048
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2744887
- OpenAlex
- W2102489568
- Cited by
- 148
- References
- 28
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- W. M. Keck Foundation
- National Institutes of Health (RR08079)
- National Institute on Aging (AG22034, R01AG022034)
- National Center for Research Resources (RR 08079, P41RR008079)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- Alzheimer's disease, amyloid plaques, transgenic mice, plaque detection, plaque burden, thioflavin S staining, iron staining, non-invasive imaging, ex vivo MRI
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Brain Mapping, Disease Models, Animal, Magnetic Resonance Imaging, Mice, Transgenic, Staining and Labeling, Thiazoles, Mice, Benzothiazoles, Plaque, Amyloid
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