Developmental Expression of Ca 2+-Permeable AMPA Receptors Underlies Depolarization-Induced Long-Term Depression at Mossy Fiber–CA3 Pyramid Synapses

Ho, Michelle T.-W.; Pelkey, Kenneth A.; Topolnik, Lisa; Petralia, Ronald S.; Takamiya, Kogo; Xia, Jun; Huganir, Richard L.; Lacaille, Jean-Claude; McBain, Chris J.

doi:10.1523/jneurosci.2671-07.2007

Developmental Expression of Ca 2+-Permeable AMPA Receptors Underlies Depolarization-Induced Long-Term Depression at Mossy Fiber–CA3 Pyramid Synapses

Many central excitatory synapses undergo developmental alterations in the molecular and biophysical characteristics of postsynaptic ionotropic glutamate receptors via changes in subunit composition. Concerning AMPA receptors (AMPARs), glutamate receptor 2 subunit (GluR2)-containing, Ca 2+ -imperm…